斑块RADS与轻度/中度狭窄性脑血管事件风险相关:一项CARE II研究
Maoxue Wang1, Yin Guo1, Daniel S Hippe1
1From the Department of Radiology (M.W., M.M.B.) and Department of Bioengineering (Y.G.), University of Washington, Seattle, Washington, USA; Department of Radiology (M.W., B.Z.), The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; Clinical Research Division (D.S.H.), Fred Hutchinson Cancer Center, Seattle, Washington, USA; Department of Biomedical Engineering (X.Z.), Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China; Department of Radiology and Imaging Sciences (C.Y.), University of Utah, Salt Lake City, Utah, USA; Department of Radiology (L.S.), University of Cagliari, Cagliari, Italy.
冠状动脉斑块报告和数据系统 (Plaque-RADS) 能够有效地识别与脑血管事件相关的高风险冠状动脉斑块. 有吸烟史的老年男性患有更高斑块-RADS分数的风险增加.
科学领域:
- 血管成像 血管成像
- 心血管研究研究心血管研究
- 神经学 神经学
背景情况:
- Carotid 斑块的形态和组成对于评估脑血管事件风险至关重要.
- 需要标准化的报告系统来进行一致的斑块评估.
- Carotid Plaque-Reporting 和数据系统 (Plaque-RADS) 提供了一个标准化的方法.
研究的目的:
- 为了在多中心,血管壁MRI数据集中评估带斑块-RADS.
- 评估斑块-RADS,临床风险因素和双侧脑血管症状之间的关系.
主要方法:
- 从CARE-II研究中招募了患有动脉样硬化性心血管斑块的症状患者.
- 利用对比度增强的血管壁成像来识别斑块成分并确定斑块-RADS.
- 收集了诸如化和斑块负担 (max_NWI) 等辅助特征;分类了狭窄症的严重程度.
主要成果:
- 与无症状侧面相比,有症状的动脉有较高的狭窄,斑块-RADS得分 (≥3) 和max_NWI.
- 斑块-RADS与脑血管事件有显著的相关性 (OR=1.11).
- 较高的斑块-RADS与晚年,男性性别和吸烟史相关.
结论:
- 斑块-RADS可以对患有脑血管事件风险的患者进行分层,特别是在轻度至中度狭窄病例中.
- 高龄,男性性别和吸烟史与较高的斑块-RADS得分有关.
- 斑块-RADS与事件之间的关联需要进一步调查,特别是经过对狭窄和斑块负担进行调整后.
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