前列腺癌和痴呆症之间的关联:瑞典的一项全国性研究
Casey Crump1, Pär Stattin2, James D Brooks3
1Department of Family and Community Medicine, The University of Texas Health Science Center, Houston, TX, USA; Department of Epidemiology, The University of Texas Health Science Center, Houston, TX, USA.
European urology oncology
|April 25, 2025
概括
患有高风险前列腺癌的男性接受了雄激素缺乏治疗,面临阿尔茨海默病和血管痴呆的风险增加. 患有痴呆症的患者随后患前列腺癌的风险较低,可能是由于查减少.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 前列腺癌 (PC) 和痴呆症经常同时发生,但证据表明它们的双向关系是不一致的.
- 了解这些关联对于为临床护理和患者管理提供信息至关重要.
研究的目的:
- 为了研究前列腺癌和痴呆风险之间的关联,在一个庞大的基于人口的队列中.
- 检查PC男性痴呆风险,考虑PC治疗方式.
- 评估先前被诊断为痴呆症的男性PC的风险.
主要方法:
- 瑞典的一项全国性队列研究包括178,746名患有PC的男性和1,787,460名对照人,分析痴呆风险 (阿尔茨海默病[AD]和血管痴呆症[VaD]).
- 对于PC患者的痴呆症的Cox回归估计危险比率 (HRs) 和痴呆症患者的PC的逻辑回归估计几率比率 (ORs).
- 分析根据社会人口统计学因素和医疗保健利用情况进行了调整,并对PC治疗效果进行了子分析.
主要成果:
- 接受抗雄激素剥夺疗法 (ADT) 治疗的高风险PC男性显示ADD (HR, 1.37) 和VaD (HR, 1.51) 的风险增加.
- 患有低或中等风险PC的男性患有AD或VaD的风险很小或没有增加.
- 患有AD或VaD的男性随后PC诊断的几率明显较低,高风险 (OR,0.39) 和低/中等风险 (OR,0.30).
结论:
- 接受ADT治疗的高风险前列腺癌患者需要监测痴呆症,因为AD和VaD的风险增加.
- 在患有痴呆症的男性中观察到较低的PC后续风险可能与该人群中癌症查减少有关.
- 调查结果强调了在PC管理中考虑痴呆风险的重要性,特别是对于那些使用ADT的人来说.
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