对比神经调节的目标,以减少吸烟的渴望和戒烟:一个随机临床试验
Nicole Petersen1, Michael R Apostol2, Timothy Jordan2,3
1Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. npetersen@ucla.edu.
概括
重复性横性磁性刺激 (TMS) 针对上额头 (SFG) 显示出减少吸烟渴望和戒烟症状的希望,特别是在男性中. 需要进一步的研究来证实它在戒烟方面的有效性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 吸烟是可预防的死亡的主要原因之一.
- 迫切需要新的治疗方法来戒烟.
- 重复性横磁性刺激 (TMS) 是一种潜在的非侵入性神经调节技术.
研究的目的:
- 调查针对特定大脑区域的TMS在减少吸烟渴望和戒烟的有效性.
- 检查TMS对正规大脑网络内部和之间功能连接的影响.
- 为了探索吸烟戒断TMS的反应中潜在的性别差异.
主要方法:
- 一个随机临床试验 (N=72) 涉及DSM-5烟草使用障碍的参与者.
- 单个会话的TMS应用于背侧前额叶皮层 (dlPFC),上额叶 (SFG),后额叶皮层 (PPC) 或对照区域 (v5).
- 在TMS之前和之后评估渴望,戒断,负面影响和休息状态的功能连接.
主要成果:
- 与对照组相比,SFG刺激显著减少了渴望和戒断症状.
- 这些影响在男性中比女性更为明显.
- dlPFC刺激改变了体运动,默认模式和背部注意网络的连接性,而SFG刺激没有显著改变网络连接性.
结论:
- 上额回 (SFG) 是基于TMS的戒烟干预措施的有希望的目标,特别是男性吸烟者.
- 需要进一步的研究来验证这些发现,并开发用于个性化神经调节的成像生物标志物.
- TMS为吸烟障碍提供了一个潜在的非侵入性治疗选择.
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