通过整合计算分析和实验验证验,探索Benincasa hispida提取物对与肥胖相关的炎症性肠病的疗效
Santosh B Patil1, Manisha B Kuvalekar1, Deepak A Yaraguppi2
1KLE College of Pharmacy, Hubballi, 580031, Karnataka, India.
Scientific reports
|April 25, 2025
概括
贝尼卡萨希斯皮达显示了与肥胖相关的炎症性肠病 (IBD) 的治疗潜力. 在和体内研究中确定了关键的分子标,并证明了对大鼠饮食诱导的IBD的保护作用.
科学领域:
- 药理学和天然产品研究 药理学和天然产品研究
- 胃肠病学和代谢疾病研究研究
背景情况:
- 肥胖与炎症性肠病 (IBD) 联系在一起,通过像阿迪波金这样的细胞因子,结构上类似于瘤缩因子-α (TNF-α).
- 鉴定与肥胖相关的IBD的新型治疗策略是至关重要的,因为代谢和炎症途径的复杂相互作用.
研究的目的:
- 评估Benincasa hispida化合物对与肥胖相关的IBD的治疗潜力.
- 为了研究贝尼卡萨 (Benincasa) hispida提取物的分子机制和体内疗效.
主要方法:
- 计算分析包括网络药理学,化合物基因组路径丰富,利宾斯基的五项规则,Protox安全评估,分子对接和分子动力学模拟.
- 数据库分析 (基因卡,OMIM,STRING,KEGG) 以确定治疗目标和途径.
- 在体内研究中,使用Wistar大鼠暴露于微塑料和单谷氨酸 (MSG) 来诱导与肥胖相关的IBD,随后进行了遗传病学和便脂质分析.
主要成果:
- 在18种贝宁卡萨酸化合物中,有11种具有良好的药物相似性. 阿贾马林对MTOR蛋白标具有强烈的结合亲和力.
- 路径丰富分析确定了192条路径,其中8条直接与肥胖和IBD病原发生有关. MTOR被强调为一个关键的治疗点.
- 在体内研究表明,Benincasa hispida提取物在老鼠中减轻了由MSG和微塑料诱导的肝脏和肠道的炎症变化.
结论:
- 贝尼卡萨·希斯皮达 (Benincasa hispida) 拥有具有显著治疗潜力的化合物,可以通过向关键分子通路,如MTOR来控制与肥胖相关的IBD.
- 提取物在体内模型中表现出保护作用,支持其作为IBD和肥胖症可行的治疗干预措施的调查.
关键词:
贝尼纳卡萨是他的第一个.IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD微塑料是一种微塑料.分子对接 分子对接分子动力学分子动力学单谷氨酸盐是一种固醇.网络药理学 网络药理学肥胖问题 肥胖问题更多相关视频
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