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稳定的胸痛和胃癌之间的关联:双样本双向孟德尔随机化研究
Haoyu Zhao1, Xintong Ye1, Chuying Yu1
1Hangzhou TCM Hospital of Zhejiang Chinese Medical University (Hangzhou Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.
Journal of thrombosis and thrombolysis
|April 25, 2025
概括
本研究使用孟德尔随机化研究了稳定性胸痛 (SAP) 和胃癌 (GC) 之间的因果关系. 研究结果表明,SAP可能会降低GC风险,但反向关系需要进一步研究.
科学领域:
- 心血管流行病学心血管流行病学
- 胃肠道瘤学 胃肠道瘤学
- 遗传流行病学遗传流行病学
背景情况:
- 稳定性胸痛 (SAP) 和胃癌 (GC) 具有共同的风险因素和病理生理路径,包括氧化应激.
- 现有的流行病学数据表明SAP和GC之间存在潜在的反向关系,但因果推理仍然具有挑战性.
研究的目的:
- 通过使用强大的孟德尔随机化方法,研究稳定的胸痛和胃癌之间的潜在双向因果关系.
- 评估SAP的遗传倾向是否会影响发展GC的风险,反之亦然.
主要方法:
- 进行了双样双向孟德尔随机化分析,使用来自大型全基因组关联研究 (GWAS) 的总结统计数据.
- 与SAP和GC相关的遗传变异作为工具变量.
- 敏感性分析包括MR-Egger拦截,MR-PRESSO,Cochran Q测试和留出一个方法,用于评估性和结果的稳定性.
主要成果:
- 门德尔随机分析表明,稳定性胸痛对胃癌风险具有显著的保护作用 (OR=0.78,P=0.000027).
- 相反,胃癌作为暴露的分析显示了与SAP的显著关联 (OR=0.87,P=0.024),但灵敏度分析显示了潜在的类,质疑了这一方向的可靠性.
- SAP-to-GC发现的稳定性得到了敏感性分析的支持.
结论:
- 遗传证据表明,稳定的胸痛可能会因果性地降低胃癌的风险.
- 胃癌对稳定性胸痛的潜在因果作用是不太确定的,因为有证据表明性.
- 需要进一步的研究来阐明这些条件之间的复杂相互作用,可能涉及氧化应激途径.
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