久坐不动的行为和患慢性病的风险:系统性审查和元分析
Luwen Zhang1, Fangli Liu2,3, Mengjie Li1
1School of Nursing and Health, Henan University, Kaifeng, Henan, China.
International urology and nephrology
|April 25, 2025
概括
长时间的久坐行为会增加成年人患慢性病 (CKD) 的风险. 这种风险在休时间的久坐活动中特别高,这突显了严重的公共卫生问题.
科学领域:
- 公共卫生 公共卫生
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 久坐不动的行为是全球公共卫生问题,被认为是独立于身体活动的不良健康结果的危险因素.
- 关于久坐不动行为与慢性病 (CKD) 风险之间的关联的先前研究已经产生了不一致的结果.
- 本次元分析旨在澄清久坐行为与患CKD的风险之间的关系.
研究的目的:
- 系统地评估静坐行为与慢性病 (CKD) 风险之间的关联.
- 综合来自多个队列研究的证据,以提供可靠的风险估计.
- 探索现有文献中异质性的潜在来源.
主要方法:
- 在11个数据库中对相关队列研究进行了全面的文献搜索.
- 聚合效应大小,表达为相对风险 (RR) 与95%置信区间 (CI),使用随机效应模型计算.
- 进行了子组,敏感性和出版偏差分析,以评估研究结果的可靠性.
主要成果:
- 八个队列研究包括996,489名参与者被纳入了元分析.
- 总体而言,静坐行为与CKD风险增加之间发现了统计学上显著的积极关联 (RR = 1.15,95% CI 1.08,1.21).
- 休时间的久坐行为 (RR = 1.26,95% CI 1.16,1.37) 和联合的久坐行为 (RR = 1.16,95% CI 1.08,1.25) 与CKD风险有显著的积极关联.
结论:
- 长时间的久坐行为,特别是在休时间,与成年人患CKD的风险显著增加有关.
- 研究区域被确定为异质性的来源,这表明地理因素可能会影响这种关联.
- 虽然研究结果表明存在明显的联系,但剩余的混因素需要在未来的研究中加以考虑.
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