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炎症指数在急性大动脉剖析患者住院死亡率的预测值

Yijing Xin¹, Siqi Lyu¹, Jingyang Wang¹

¹Emergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

BMC cardiovascular disorders

|April 25, 2025

概括

高入院炎症指数,包括中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR) 和全身免疫炎症指数 (SII),与急性大动脉切割 (AAD) 患者的住院死亡风险增加有关.

科学领域:

心血管医学心血管医学
炎症研究炎症研究
医学诊断医学诊断医学诊断

背景情况:

急性大动脉解剖 (AAD) 是一种危及生命的疾病,死亡率高.
入院炎症标志物越来越被认为是危急疾病的潜在预后指标.
在AAD结果中特定炎症指数的预测价值需要进一步调查.

研究的目的:

评估入院炎症指数 (NLR,MLR,SII) 与AAD患者在医院内全因死亡率之间的关系.
确定这些炎症标志物是否可以作为AAD死亡率的预测因素.
探索这些指数与死亡风险之间的相关性模式 (线性,非线性).

主要方法:

对597名AAD患者 (斯坦福A型和B型) 的回顾性分析.
使用卡普兰-梅尔曲线,比较低和高炎症指数组之间的死亡风险.
通过考克斯回归和限制立方线 (RCS) 评估炎症指数和结果之间的关联.
根据AAD类型,年龄和性别进行分层分析.

主要成果:

较高的炎症指数 (NLR,MLR,SII) 与增加住院死亡风险显著相关.
单细胞与淋巴细胞比率 (MLR) 显示出与死亡率的最强相关性.
中性粒细胞与淋巴细胞的比率 (NLR) 显示出非线性,J形相关性,而MLR和SII显示出与死亡率的线性相关性.
在死亡风险方面观察到炎症指数和AAD类型/年龄之间的相互作用.

结论:

升高的入院炎症指数是AAD患者医院死亡率增加的独立预测指标.
中性细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR) 和全身免疫炎症指数 (SII) 可以成为预测AAD死亡率的有价值工具.
这些发现支持在AAD患者的风险分层中使用炎症标志物.

关键词:

急性大动脉切割.激发性指数的指数单细胞与淋巴细胞的比率.中性粒细胞与淋巴细胞的比率.系统性免疫炎症指数

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