三甘油-葡萄糖指数和心血管死亡率之间的非线性关系与18-80岁人口的竞争性风险分析
Jianchun Yao1, Jinping Lu2, Linfen Li3
1Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Jinping District, Shantou, Guangdong, 515000, China.
BMC cardiovascular disorders
|April 25, 2025
概括
甘油三糖 (TyG) 指数显示,与心血管死亡风险有显著的积极关联,即使考虑到非心血管死亡. 当TyG指数超过9.4.4的值时,这种风险显著增加.
科学领域:
- 心血管流行病学心血管流行病学
- 代谢综合征研究研究
- 生物标志物的分析分析.
背景情况:
- 有限和有争议的证据存在于甘油三糖 (TyG) 指数和心血管死亡率.
- 在这种关联中,非心血管死亡率作为竞争风险的影响需要进一步调查.
研究的目的:
- 调查TyG指数与心血管死亡率之间的关系.
- 将非心血管疾病死亡率纳入竞争性风险事件.
- 探索潜在的非线性关联和值效应.
主要方法:
- 利用了1999-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用传统的考克斯比例危险回归和细灰子分布危险模型.
- 应用受限立方线,细分回归和日志概率比率测试来评估非线性并确定值.
主要成果:
- 分析了23800名参与者的队列,平均年龄为47.75岁.
- 一项完全调整的分析显示,TyG指数与心血管死亡率 (HR=1.24) 之间存在显著的正相关性.
- 细灰模型证实了显著的积极关联,即使考虑到非心血管死亡率 (sHR=1.11).
- 确定了一种非线性,反向的L形关系,TyG指数的值为9.4.
- 65岁以下的个人和正常BMI的个人对这种风险的敏感性更高.
结论:
- 三甘油-葡萄糖指数与18-80岁成年人心血管死亡风险增加有着强烈的联系.
- 这种关联是非线性的,风险在TyG指数9.4.4之后显著升级.
- 年轻人 (≤65岁) 和体重指数正常的人可能特别容易受到与提升的TyG指数相关的心血管风险的影响.
相关概念视频
Comparing the Survival Analysis of Two or More Groups
85
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
85
Hypoglycemia and Glucagon
138
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
138
Overview of Carbohydrate Metabolism
535
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
535
Overview of Lipid Metabolism
802
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
802
Kaplan-Meier Approach
55
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
55
Blood Studies for Cardiovascular System III: Serum Lipid Profile
100
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
100


