非洲的胃病的流行和模式:系统性审查和元分析
Seid Mohammed Abdu1, Ebrahim Msaye Assefa2, Hussen Abdu2
1Department of Biomedical Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia. seidmd041@gmail.com.
胃潰瘍疾病 (PUD) 影響15.2%的非洲人,其中十二指腸潰瘍是最常見的. 患病率因地区而异,西非的患病率最高,Helicobacter pylori感染在PUD患者中很常见.
科学领域:
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 胃潰瘍疾病 (PUD) 在非洲是一個重大的公共衛生挑戰,在不同地區報告的流行率各不相同.
- 了解负担,模式 (十二指肠与胃) 以及与H. pylori感染的关联至关重要.
研究的目的:
- 系统地审查和元分析非洲人口中PUD的综合流行率和模式.
- 确定非洲各地的PUD负担的区域变化和趋势.
主要方法:
- 对58项遵循PRISMA指南的观察性研究进行了系统审查和元分析.
- 数据提取和质量评估由两位独立审查员进行.
- 随机效应模型用于聚合流行率估计,使用Cochrane Q和I2统计数据评估异质性.
主要成果:
- 在非洲,发现了15.2%的PUD综合患病率,十二指甲状腺 (DU) 比胃 (GU) (5.8%) 更常见 (10.2%).
- 西非地区患病率最高 (19%),加纳国家患病率最高 (27%).
- 在57.1%的患者中存在Helicobacter pylori感染,在PUD患者中增加到76.4%;在研究中注意到了大量的异质性 (I2>95%).
结论:
- 在非洲,PUD对健康造成重大负担,其特点是 DU 的发病率较高,区域差异很大.
- 在过去的二十年中,PUD的患病率保持相对稳定,这表明持续存在的公共卫生问题.
- 尽管有相当大的研究异质性,但H. pylori感染的高率凸显了它在非洲背景下PUD病变发生中的可能作用.
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