在固体器官移植接受者中,SARS-CoV2疫苗接种后的长期免疫反应
Cecilia Bonazzetti1,2, Alice Toschi1, Dino Gibertoni3
1Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
BMC infectious diseases
|April 25, 2025
概括
细胞介导免疫 (CMI) 在SARS-CoV-2疫苗接种后的固体器官移植 (SOT) 接受者中没有预测突破性感染 (BI). 这一发现表明CMI不是在这个脆弱人群中疫苗有效性的可靠标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 固体器官移植 (SOT) 接受者对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗表现出低于最佳的抗体反应,增加突破性感染 (BI) 风险.
- 细胞介导免疫 (CMI) 对SOT接种者疫苗有效性的贡献尚不清楚.
研究的目的:
- 研究细胞介导免疫 (CMI) 作为在SOT接种者接种SARS-CoV-2疫苗后突破性感染 (BI) 的预测因素的作用.
- 为了评估CMI和BI之间的关系,在一队SOT患者中进行了后续接种疫苗接种.
主要方法:
- 一个单一中心前性纵向队列研究,涉及成年SOT接受者.
- 在SARS-CoV-2增剂疫苗接种后6 ± 2个月内监测抗体反应 (AbR) 和CMI.
- 用双变量和多变量逻辑回归分析BI发生率及其与CMI的相关性.
主要成果:
- 在分析的73名SOT接收者中,有30.1%的人经历过BI.
- 在阳性与阴性CMI患者之间没有观察到BI率的显著差异 (59.1%与40.9%,p=0.798).
- 经相关因素调整的多变量后勤回归证实CMI不是BI的重要预测因素.
结论:
- 细胞介导免疫 (CMI) 似乎不是在SOT接受者中突破性感染 (BI) 的强有力的预测因素.
- 这些发现表明,CMI可能不是这种免疫受损人群中疫苗有效性的可靠替代标志物.
- 可能需要进一步的研究来确定在SOT接收者中对抗SARS-CoV-2感染的强有力的保护相关物.
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