使用生物制剂的儿童和青少年结核病:土耳其全国的队列研究
Tugba Sismanlar Eyuboglu1, Ayse Tana Aslan2, Volkan Medeni3
1Faculty of Medicine, Department of Pediatric Pulmonology, Gazi University, Ankara, Turkey. tsismanlar@yahoo.com.
BMC pulmonary medicine
|April 25, 2025
概括
生物制剂增加了儿童结核病的风险,导致更早的诊断年龄和更广泛的疾病. 在这些儿童中使用纳普洛克森进一步增加了肺结核风险,需要密切监测.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 传染性疾病 传染性疾病
- 药物监督 药物监督 药物监督
背景情况:
- 在儿科疾病管理中使用生物制剂正在增加,与肺结核 (TB) 风险增加相关.
- 强制性结核病查协议已在适度结核病流行的国家适用于开始生物治疗的患者.
研究的目的:
- 调查生物制剂使用与儿童结核病发病率之间的关联.
- 确定使用生物药物治疗的儿科患者结核病的危险因素和临床特征.
主要方法:
- 追溯队列研究分析了2018-2023年国家健康数据库记录.
- 纳入标准:儿童患者 (0-18岁) 诊断出结核病.
- 使用生物制剂和不使用生物制剂的儿童之间的比较,记录人口统计,治疗和结核病参与.
主要成果:
- 在4351例儿科结核病病例中,有1.9%涉及使用生物制剂的儿童.
- 接受生物药物治疗的儿童在较早的年龄被诊断出肺结核,肺结核和肺外结核的发病率更高.
- 纳普洛克森使用与儿童在生物药物治疗中的肺结核风险增加有关 (OR:3.824).
结论:
- 有效的结核病查可能有助于在这个队列中观察到的结核病的低频率.
- 儿童使用生物药物的结核病发病率和严重程度增加可能源于免疫抑制作用.
- 密切的肺结核监测对于接受生物药物治疗的儿科患者至关重要,特别是那些同时使用纳普洛森的儿科患者.
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