手术后瘤复发的预测因素:一个单心研究
Zhuoran Li1, Dong Lai2, Yuqi Jia1
1Medical School of Nankai University, Tianjin, China.
BMC surgery
|April 25, 2025
概括
手术后染细胞瘤 (PCC) 的复发受到几个因素的影响. 独立的风险因素包括年龄,高血压,以前的PCC复发,家族病史,双边瘤,瘤大小和手术内血动力学不稳定性.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 瘤病理学 癌症病理学
背景情况:
- 乳色细胞瘤 (PCC) 是一种罕见的神经内分泌瘤,起源于色素细胞.
- 手术切除是PCC的主要治疗方法.
- 了解复发风险因素对于长期患者管理至关重要.
研究的目的:
- 识别和分析与手术管理后染细胞瘤复发相关的风险因素.
- 为预测和潜在地减轻手术后PCC复发提供洞察力.
主要方法:
- 在2012年至2020年期间,对451名被诊断患有PCC并接受手术治疗的患者进行了回顾性审查.
- 分析临床数据,包括患者人口统计,瘤特征,手术细节和后续信息.
- 应用单变量和多变量COX回归分析来确定复发的独立风险因素.
主要成果:
- 在451名患者中,有35名患者 (7.85%) 经历了PCC复发.
- 单变量分析发现了许多潜在的风险因素,包括年龄,高血压,瘤双边性和手术内不稳定性.
- 多变量分析揭示了年龄,高血压,之前的PCC复发,高血压家族史,双边瘤,瘤大小,以及手术内血动力学不稳定的发作/持续时间作为复发的独立预测因素.
结论:
- 几个因素独立地预测了手术后染细胞瘤复发.
- 关键预测因素包括患者相关因素 (年龄,高血压,家族病史),瘤特征 (双边,大小) 和手术事件 (血液动力学不稳定).
- 这些发现有助于对PCC患者进行风险分层和个性化随访策略.
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