益生菌Lactocaseibacillus caseiNK1增强了禽病原性大肠杆菌挑战型肉的生长和肠道微生物群
Nimra Khalid1,2, Syed Mohsin Bukhari2, Waqas Ali2
1Department of Animal Sciences, College of Food Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH 44691, USA.
Animals : an open access journal from MDPI
|April 26, 2025
概括
在实验室中分离的乳酸菌 (Lactocaseibacillus casei NK1 (Lc. NK1) 改善了 brojler 的生长和肠道健康. 这种益生菌增强了体重增加,并平衡了肠道微生物群,减少了致病性大肠杆菌,为抗生素提供了替代品.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 肠道健康 肠道健康
背景情况:
- 在家禽生产中使用抗生素引发了关于抗菌素耐药性的担忧.
- 探索益生菌等替代策略对于可持续的家禽养殖至关重要.
- 肠道健康显著影响肉的表现和抗病能力.
研究的目的:
- 为了评估实验室隔离的乳酪菌种病例NK1 (Lc. NK1) 在 brojlers.
- 为了确定是否Lc. 补充NK1可以提高生长性能,调节肠道微生物群,并减少致病性大肠杆菌.
- 为了评估Lc. NK1作为抗生素增长促进剂的潜在替代品.
主要方法:
- 这是一项为期35天的实验,60只肉被分配到四个组:对照组,大肠杆菌挑战组 (APEC),商业益生菌组 (CProb) 和Lc. 在NK1 (LNK1) 中.
- 肉在11天大时受到大肠杆菌O78的挑战.
- 使用了生长性能,对大肠杆菌和乳杆菌的克洛亚克抹布,以及用于元基因组分析的16SrRNA测序.
主要成果:
- LNK1组的体重增加与CProb组的体重增加相当,明显超过APEC组.
- 在LNK1和CProb两组都显示了E. coli的减少和Lactobacillus的增加.
- 甲基因组分析显示,与APEC组不同,LNK1保持了肠道微生物群的多样性,增加了Firmicutes,减少了蛋白质细菌.
结论:
- 在 Lc. NK1补充剂在增强肉生长性能和肠道健康方面表现有前途.
- 在 Lc. NK1有效调节肠道微生物群,并减少致病性大肠杆菌的殖民.
- 这项研究表明Lc. 在家禽生产中,NK1作为抗生素的可行的益生菌替代品.
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