使用卷积神经网络对同胞性和分类运行的可视化
Siroj Bakoev1,2,3, Maria Kolosova1, Timofey Romanets1
1Faculty of Biotechnology, Don State Agrarian University, Persianovsky 346493, Russia.
Biology
|April 26, 2025
概括
这项研究可视化了使用卷积神经网络 (CNN) 的同卵性 (ROH) 运行,以100%的准确性分类猪品种并识别肢体缺陷的动物. 这种新的ROH分析方法对动物育种和医学研究有很大的前景.
科学领域:
- 遗传学 是一个遗传学.
- 生物信息学是一种生物信息学.
- 机器学习 机器学习
背景情况:
- 同胞性 (ROH) 的运行对于理解基因结构,近亲繁殖和种群的选择历史至关重要.
- 传统上,ROH分析需要复杂的计算方法,这限制了其广泛应用.
研究的目的:
- 开发和验证一种使用卷积神经网络 (CNN) 进行ROH分析的新方法.
- 根据可视化的ROH地图,对猪品种进行分类并识别表型特征.
- 探索这种方法在动物育种和人类医学中的应用.
主要方法:
- 来自大白猪和杜罗猪的遗传数据被用来创建ROH地图,可视化同卵性细分.
- 卷积神经网络 (CNN) 用于分类任务:品种识别和肢体缺陷预测.
- 使用PLINK v1.9识别了ROH细分,并通过修改的HandyCNV包函数实现了可视化.
主要成果:
- 根据ROH地图,CNN模型在分类猪品种方面实现了100%的准确性,灵敏性和特异性.
- 该模型在预测肢体缺陷的存在或不存在方面显示了78.57%的准确性.
- 对于识别肢体缺陷的健康动物,观察到高负预测值 (84.62%).
结论:
- 基于CNN的ROH地图可视化提供了一个非常准确的方法来对猪进行品种分类.
- 该方法显示了识别对肢体缺陷等表型特征的遗传倾向的潜力,这对疾病关联研究有影响.
- 这种创新方法可以扩展到各种遗传数据,并在动物育种和医学研究中应用,以改善遗传洞察力.
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