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儿童T型急性淋巴细胞白血病中非编码RNA的异常表达及其作为生物标志物的潜在应用

Neila Luciano^1,2, Luigi Coppola³, Giuliana Salvatore^1,2

¹Department of Medical, Movement and Wellbeing Sciences, University of Naples Parthenope, 80133 Naples, Italy.

|April 26, 2025

概括

微RNA (miRNA) 和长非编码RNA (lncRNA) 是儿科T型急性淋巴细胞白血病 (T-ALL) 的关键表观遗传因素. 异常的 lncRNA 签名显示出作为儿童诊断和预后敏感生物标志物的前景.

科学领域:

分子生物学分子生物学
癌症研究癌症研究
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

非编码RNAs (ncRNAs),包括microRNAs (miRNAs) 和长非编码RNAs (lncRNAs),显著影响基因表达和细胞功能.
这些ncRNAs在各种癌症的发展和进展中发挥着至关重要的作用,特别是白血病.
毫米RNA和lncRNA都被认为是表观遗传调节器,影响血液细胞的分化,增殖和免疫反应.

研究的目的:

审查关于小儿T型急性淋巴细胞白血病 (T-ALL) 中miRNAs和lncRNAs分子机制的最新发现.
探索这些非编码RNA作为T-ALL.治疗标和生物标记物的潜力.
突出在儿科T-ALL中循环的长非编码RNA的诊断和预后效用.

主要方法:

关于miRNA和lncRNA参与T-ALL病变的最新发现的文献综述.
分析分子机制,包括基因表达调节,细胞亡抑制和细胞循环促进.
讨论生物标志物的潜力,包括在患者血中检测.

主要成果:

在T-ALL病变发生过程中,MiRNAs既可以作为瘤抑制剂,也可以作为瘤抑制剂.
长非编码RNAs (lncRNAs) 似乎在T-ALL中仅作为瘤基因,促进细胞存活和耐药性.
在儿童T-ALL患者中,循环的lncRNA显示出作为早期诊断,风险分层和预后的准确和敏感生物标志物的潜力.

结论:

细胞内和循环lncRNAs的异常表达特征对儿科T-ALL.具有显著的临床实用性.
了解miRNA和lncRNA的作用可以揭示新的治疗策略,并提高儿童T-ALL的预后准确性.
需要进一步的研究来标准化量化方法,并开发针对儿科T-ALL. lncRNAs的向疗法.

关键词:

生物标志物生物标志物在ncRNA中,我们可以这是一个小RNARNA.儿科T-ALL 的情况.治疗目标是治疗的目标.

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