优化卡博赞提尼布剂量在非切除性肝细胞癌的7-on/7-off疗法
Yudai Fujiwara1, Hidekatsu Kuroda1, Tamami Abe1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Iwate 0283695, Japan.
在不可切除的肝细胞癌 (u-HCC) 中,卡博桑提尼布 (CAB) 的7对7治疗方案显示,与每日剂量相比,存活率改善,不良事件减少. 这种剂量计划可以提高u-HCC患者的耐受性和治疗反应.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 医学瘤学 医学瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 卡博桑提尼布 (CAB) 与不可切除的肝细胞癌 (u-HCC) 的显著不良事件有关,往往需要剂量调整.
- 由于毒性,CAB的标准每日剂量可以限制治疗持续时间和疗效.
研究的目的:
- 评估7日7晚卡博桑提尼布 (CAB) 治疗方案在无法切除的肝细胞癌 (u-HCC) 患者中的疗效和安全性.
- 为了比较7-on/7-off CAB疗法和u-HCC的每日剂量之间的临床结果.
主要方法:
- 在2020年至2024年期间,在日本多个中心对35名u-HCC患者接受CAB治疗的回顾性分析.
- 对12名7次7次治疗方案的患者和23名每日服用剂量的患者的结局进行比较.
主要成果:
- 7个/7个小组的整体存活时间显着更长 (12.4 vs. 6.3个月,p=0.03) 和无进展存活时间 (4.8 vs. 3.2个月,p<0.01).
- 客观反应率较高 (16.7%对比0.0%,p=0.04) 和任何不良事件的发生率较低 (75.0%对比100.0%,p=0.03) 在7-on/7-off组.
- 药物暴露的中位数 (122 vs. 42天,p<0.01) 和剂量减少的持续时间 (100 vs. 23天,p<0.01) 在7日/7日的治疗方案中显著延长.
结论:
- 卡博桑提尼布7对7的治疗方案可能会在患有不可切除的肝细胞癌的患者中提供更好的耐受性和治疗反应.
- 这种间歇性剂量计划需要进一步调查,以管理u-HCC.
更多相关视频
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
09:49Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
Published on: December 2, 2013
相关概念视频
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Drug Dosage Regimen: Overview
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Rational Dosage Regimen: Maintenance Dose and Loading Dose
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
