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在细胞癌中尿路miRNA的评估:系统性审查

Giovanni Cochetti¹, Liliana Guadagni¹, Alessio Paladini¹

¹Urology Clinic, Department of Medicine and Surgery, Santa Maria della Misericordia Hospital, University of Perugia, 06129 Perugia, Italy.

|April 26, 2025

概括

这一系统性审查分析了尿路微RNA (miRNAs) 以诊断细胞癌 (RCC). 在RCC患者中,miR-210和let-7家族的高调,手术后水平下降.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物生物标志物

背景情况:

微RNAs (miRNAs) 越来越多地被认为是它们在瘤疾病中的作用,如细胞癌 (RCC).
尿路miRNAs显示出作为疾病检测的非侵入性生物标志物的潜力.

研究的目的:

系统地审查和分析涉及细胞癌 (RCC) 的尿路miRNAs.
评估这些尿路miRNAs对RCC的潜在诊断效用.

主要方法:

在PROSPERO协议CRD42024550716之后进行系统的文献审查.
搜索了包括PubMed,EMBASE和ClinicalTrials.gov在内的数据库,以研究RCC患者的尿路miRNA.
包括10篇论文从593个记录进行选后.

主要成果:

与对照组相比,miR-210和let-7家族是最常被研究的miRNAs,并且在RCC病例中被发现是上调的.
五项研究报告说,脏切除术后特定miRNAs (miR-15a,miR-34a-5p,miR-200a-3p,miR-205-5p,miR-210,miR-210-3p,miR-365a-3p,let-7d-5p) 的水平降低.
由于研究的miRNAs,正常化方法和RCC组织学类型的异质性,元分析是不可行的.

结论:

目前发现的异质性突出显示,需要扩大对RCC尿路miRNA分析的研究.
建立一个国际发现的集中数据库将促进该领域的未来进展.
尿中的miRNAs作为细胞癌的诊断生物标志物具有前途,需要进一步调查.

关键词:

在 RCC RCC 里面,你会发现.生物标志物生物标志物液体活检活检液体活检这是一个小RNARNA.这是一个微型RNA.细胞癌瘤是细胞癌.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...