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前列腺癌焦点治疗后的监测:全面审查

Jason Koehler¹, Simon Han², Samuel Tremblay³

¹College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.

|April 26, 2025

概括

前列腺癌 (PCa) 的焦点治疗 (FT) 需要特定的随访. 监测应结合PSA检测,mpMRI和活检,并使用特定的PSA上升值来表明潜在的复发.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医疗成像医学成像

背景情况:

焦点治疗 (FT) 是一种新兴的前列腺癌 (PCa) 治疗方法.
由于FT的新性,对FT后患者监测的研究有限.
目前的指导方针缺乏非PSA生物标志物和PSMA PET的后续作用.

研究的目的:

审查目前关于FT后PCa监测策略的文献.
总结对FT后随访中的生物标志物,成像和活检的建议.
突出了对标准监控协议的需要.

主要方法:

关于FT监控的当前研究的文献综述.
对生物标志物,成像技术和活检协议的分析.
审查共识陈述和评分系统,用于FT后的评估.

主要成果:

常规监测应包括PSA检测,多参数MRI (mpMRI) 和活检.
在PSA上升1.0 ng/mL (12个月) 或1.5 ng/mL (24-36个月) 超过最低值时,出现复发的怀疑.
像PI-FAB或TARGET这样的标准化评分系统改善了FT后的mpMRI解释的一致性.

结论:

建议PSA,mpMRI和活检的组合用于FT监测.
特定的PSA动力学和标准化的成像解释对于检测复发至关重要.
需要进一步的研究来完善监测协议,并确定新型生物标志物的作用.

关键词:

失败的失败失败的失败失败的失败焦点治疗焦点治疗前列腺癌是前列腺癌.监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督

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