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炎症和甲状腺癌:解读血液免疫指数的作用
Salvatore Sorrenti1, Gregorio Scerrino2, Eleonora Lori1
1Department of Surgery, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Cancers
|April 26, 2025
概括
系统性免疫炎症指数 (SII) 可以预测甲状腺癌 (TC) 恶性. 在TC患者中,较高的SII值与较大的瘤大小和中枢淋巴结转移相关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 瘤微环境的炎症与各种癌症有关.
- 甲状腺癌 (TC) 中炎症的作用需要进一步研究.
研究的目的:
- 探索炎症的重要性,特别是系统性免疫炎症指数 (SII),在甲状腺癌 (TC).
- 评估SII和TC特征之间的相关性,包括恶性瘤,瘤大小和淋巴结参与.
主要方法:
- 对157种甲状腺癌和40种良性病例进行了回顾性分析.
- 免疫指数的计算和分析:中性粒细胞/淋巴细胞 (NLR),血小板/淋巴细胞 (PLR),淋巴细胞/单细胞 (LMR) 和SII.
- 倾向性得分匹配以平衡恶性和良性群体.
- 多变量逻辑回归包括年龄,性别,中枢淋巴结转移 (CLNM) 和SII.
- 接收器操作特征 (ROC) 曲线分析以确定SII截止值.
主要成果:
- 在单变量和多变量分析中,SII指数是恶性瘤的显著预测指标 (p=0.0202).
- 465.71的最佳SII切线显示了80%的敏感性和58%的特异性来检测恶性瘤.
- 在较大的瘤 (>1厘米与≤1厘米;p=0.016) 和中枢淋巴结转移病例 (CLNM>0与CLNM = 0;p=0.011) 中,中位数SII值显著更高.
结论:
- 系统性免疫炎症指数 (SII) 是甲状腺癌 (TC) 诊断中的一个有价值的指标.
- SII与瘤恶性,大小和中枢淋巴结转移的存在显著相关.
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