对基于乳液的Nisin输送系统进行全面的审查,以确保食品安全
John Kapolos1, Dimitra Giannopoulou2, Konstantinos Papadimitriou3
1Department of Food Science and Technology, School of Agriculture and Food, University of the Peloponnese, 24100 Kalamata, Greece.
Foods (Basel, Switzerland)
|April 26, 2025
概括
尼辛是一种安全的抗微生物,对抗阴性细菌的有效性有限. 封装和与其他药物结合,可增强其在食品系统中的抗菌活性.
科学领域:
- 食品科学与技术 食品科学与技术
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
背景情况:
- 食物传播疾病对食品工业和消费者健康构成重大风险.
- 尼辛是一种来自*Lactococcus lactis*的细菌素,是一种一般公认的安全 (GRAS) 抗微生物,有效对抗阳性细菌.
- 尼辛的有效性可能会受到食品基质相互作用,蛋白质分解和其他食品成分的影响.
研究的目的:
- 审查尼单独或与其他抗菌剂结合在各种乳液类型中的使用情况.
- 探索增强尼抗菌活性的策略,特别是对抗阴性细菌.
- 讨论基于尼的输送系统的物理化学表征的技术.
主要方法:
- 文献综述侧重于尼在食品系统中的应用.
- 对将尼与精油或其他抗微生物化合物结合的研究进行分析.
- 在纳米输送系统中检查尼封装,以提高稳定性和可控释放.
- 对含尼乳液的标准物理化学表征方法的概述.
主要成果:
- 尼辛的有效性往往受食品矩阵成分和易受降解的敏感性限制.
- 尼与精油或其他抗微生物药物的组合显示,它有望扩大其对抗格兰氏阴性细菌的谱.
- 纳米输送系统中的封装有效地保护尼并调节其释放,提高其稳定性和性能.
结论:
- 尼辛是一种有价值的抗菌剂,但纳米封装和协同组合等策略对于优化其在各种食品中的应用至关重要.
- 对基于尼的输送系统和组合进行进一步的研究对于对抗更广泛的食源性病原体和确保食品安全至关重要.
相关概念视频
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Overview
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...


