类风湿性关节炎患者的萨尔科佩尼亚肌肉功能特征:一个大规模的现实世界的横截面研究
Pei-Wen Jia1, Jian-Zi Lin1, Yao-Wei Zou1
1Department of Rheumatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan Jiang West Road, Guangzhou 510120, China.
Medicina (Kaunas, Lithuania)
|April 26, 2025
概括
年轻患者的活性类风湿性关节炎 (RA) 与肌肉力量的恶化有关,而不仅仅是减少身体功能. 在RA中早期发现肌肉功能障碍对于改善患者生活质量至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
背景情况:
- 肌肉损失和肌肉衰弱的特征是萨尔科佩尼亚,是类风湿性关节炎 (RA) 的常见并发症,约占患者的三分之一.
- 肌肉功能的特定特征及其与RA疾病活性和患者人口统计学相关的相关性仍然不完全理解.
研究的目的:
- 在现实中华风湿关节炎队列中调查缩症及其组成部分 (肌盲,低肌肉功能) 的患病率和特征.
- 探索RA患者肌肉功能障碍,年龄和疾病活动之间的关联.
主要方法:
- 一项横截面研究分析了928名符合条件的RA患者的临床数据.
- 萨科佩尼亚是由尾骨肌肉质量指数 (ASMI),手握力 (LMS) 和6米步行速度 (LPP) 定义的.
- 患者被分为年轻 (<50岁) 和老 (≥50岁),缓解 (CDAI ≤2.8) 和活跃 (CDAI >2.8) 的子组.
主要成果:
- 麻症,肌症,低肌肉功能 (LMF),低肌肉力量 (LMS) 和低体能 (LPP) 的患病率分别为36.5%,46.1%,69.0%,57.8%和37.1%.
- 与缓解子组相比,年轻的患有活跃疾病的RA患者 (CDAI > 2.8) 显着表现出较低的握力,较高的麻症,LMF和LMS患病率.
- 多变量分析表明,年轻和活跃的RA亚组与肉症 (OR = 3.193),LMF (OR = 2.390),和LMS (OR = 3.520) 有积极的关联.
结论:
- 更糟糕的肌肉力量在年轻的RA患者中更为普遍,而不是减少体力表现.
- 这些发现凸显了针对RA肌肉功能障碍的早期检测和干预策略的关键需求.
- 积极管理肌肉健康可以显著改善RA患者的生活质量,特别是患有活跃疾病的年轻人.
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