在MRONJ管理中富含血小板的纤维素:对其在预防和治疗中的有效性进行前性比较研究
Raluca Maracineanu1, Anca Tudor2, Ivona Hum1
1Doctoral School, "Victor Babeș" University of Medicine and Pharmacy, 300062 Timisoara, Romania.
Medicina (Kaunas, Lithuania)
|April 26, 2025
概括
富于血小板纤维素 (PRF) 的生长因子显著改善了与药物相关的骨缩 (MRONJ) 风险的患者的牙提取后的愈合. 在确诊的MRONJ病例中,PRF没有显著的治疗价值.
科学领域:
- 口腔和牙面部外科手术
- 再生医学是一种再生医学.
- 瘤科 支持性护理
背景情况:
- 与药物相关的下巴骨硬化 (MRONJ) 是牙医和外科医生日益关注的临床问题.
- 有效的预防和管理策略对于MRONJ至关重要.
- 抗吸收和抗血管原药与MRONJ风险增加有关.
研究的目的:
- 评估富血小板纤维素 (PRF) 在预防和治疗 MRONJ 的有效性.
- 在高危患者中,将PRF治疗与经典手术方法进行比较.
- 评估PRF在提取后伤口愈合和确诊的MRONJ病例中的作用.
主要方法:
- 一项前性临床研究,涉及85名服用抗吸收/抗血管原药的患者.
- 两个组:G1 (PRF生长因子) 和G2 (古典外科手术方法).
- 在2,4周和8周评估术后伤口愈合,并对并发症进行监测.
主要成果:
- 在患有MRONJ易感的患者中,PRF在96%的抽取后中帮助局部愈合,而没有PRF的患者是64.29% (p=0.016).
- 在确诊的MRONJ病例中除菌后的PRF应用没有统计学意义 (p=0.299).
- 在风险患者中,PRF和非PRF组之间治疗结果的显著差异.
结论:
- 在接受抗吸收疗法的患者中,PRF有效预防牙拔除后的骨髓瘤并发症.
- 需要进一步的研究来确定PRF在确定的MRONJ病例中的治疗作用.
- 在特定的临床场景中,PRF显示为MRONJ的预防措施.
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