术前口服抗血栓剂的类型作为部手术后静脉血栓栓塞的危险因素:一项回顾性研究
Yea-Ji Lee1, Jaemoon Lee1, Seung-Wan Hong1
1Department of Anaesthesiology and Pain Medicine, Konkuk University Medical Centre, Seoul 05030, Republic of Korea.
Medicina (Kaunas, Lithuania)
|April 26, 2025
概括
在部手术后,克洛皮多格雷尔可以预防静脉血栓塞栓症 (VTE),而西洛斯塔可以增加VTE风险. 低的手术前白蛋白水平也会提高部手术患者的静脉瘤风险.
科学领域:
- 整形外科手术 整形外科手术
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 部手术在老年患者中很常见,通常需要口服抗血栓剂治疗并发症.
- 术后出血和术后静脉血栓栓塞 (VTE) 是部手术中的重要问题.
- 手术前的口服抗血栓剂在部手术患者中具有双重风险-益处概况.
研究的目的:
- 为了研究手术前的口服抗血栓剂和部手术后的手术后的静脉血栓炎之间的关联.
- 为了确定不同口服抗血栓剂对VTE发生的具体影响.
- 在接受抗血栓治疗的部手术患者中识别VTE的风险因素.
主要方法:
- 对601名19岁以上接受关节手术的患者的回顾性分析 (2021年1月至2023年6月).
- 患者分为VTE+ (发达VTE) 和VTE- (没有VTE) 组.
- 统计分析包括多变量回归来评估相关性.
主要成果:
- 克洛皮多格雷尔的使用与静脉瘤风险降低有关 (OR=0.278,p=0.038).
- 锡洛斯塔的使用与静脉瘤风险增加有关 (OR=6.479,p=0.010).
- 手术前较低的白蛋白水平与较高的静脉瘤发病率显著相关 (OR=0.285,p=0.004).
结论:
- 在部手术中,克洛皮多格雷尔可能会对术后静脉瘤产生保护作用.
- 奇洛斯塔似乎加剧了在这个患者群体中术后静脉瘤的风险.
- 手术前的低albuminemia是部手术后VTE的重要危险因素.
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