多发性硬化症的环境和家庭风险因素:来自沙特阿拉伯队列的见解
Mubarak Alruwaili1, Rehana Basri1
1Department of Internal Medicine, College of Medicine, Jouf University, Sakaka 72388, Saudi Arabia.
Medicina (Kaunas, Lithuania)
|April 26, 2025
概括
沙特阿拉伯的多发性硬化症 (MS) 风险因素包括低阳光照射,吸烟和肥胖. 保护因素包括足够的阳光照射,母乳养和鱼类消费,突出了公共卫生干预的领域.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 全球MS发病率正在上升,沙特阿拉伯的发病率显著上升.
- 了解区域风险因素对于有针对性的预防策略至关重要.
研究的目的:
- 调查沙特阿拉伯阿尔朱夫地区MS的环境,生活方式和家族风险因素.
- 为了确定与MS发展相关的风险和保护因素.
- 为该地区的MS预防提供公共卫生倡议的信息.
主要方法:
- 在阿尔朱夫地区对155名经过临床诊断的多发性硬化症患者进行了横截面研究.
- 通过结构化问卷和医疗记录审查收集的数据.
- 分析包括社会人口统计数据,阳光照射,吸烟,肥胖,饮食和儿童感染.
主要成果:
- 日常阳光照射不足 (<15分钟/天),吸烟,肥胖和儿童麻疹感染是显著的MS风险因素.
- 显著的周末阳光照射 (>4小时/天),纯母乳养和定期食用鱼类显示出保护作用.
- 家庭MS病史在统计学上显著 (5.5%),但父母血缘关系没有 (p=0.07).
结论:
- 多发性硬化症的病因是复杂的,受可修改的环境和生活方式因素的影响.
- 预防策略应侧重于提高维生素D水平,戒烟,控制肥胖和改善饮食.
- 解决这些可控制的风险因素可能会降低沙特阿拉伯的MS患病率.
关键词:
沙特阿拉伯 沙特阿拉伯 沙特阿拉伯自身免疫性疾病 自身免疫性疾病血缘关系是一种血缘关系.饮食因素 饮食因素环境影响环境影响遗传风险因素 遗传风险因素多发性硬化症多发性硬化症肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖吸烟是为了吸烟.暴露在阳光下的时间.更多相关视频
05:44Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
Published on: October 13, 2023
1.2K
05:53Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.1K
相关概念视频
Autism Spectrum Disorder
34
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
34
Genome-wide Association Studies-GWAS
12.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.1K
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Single Nucleotide Polymorphisms-SNPs
13.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
13.6K
Meiosis I
191.6K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
191.6K
Autoimmune Disorders
313
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
313
