在亚洲族群中,IV期NSCLC的生存结果的变化
Aria Bassiri1, Yue-Lin Hu2, Christina Boutros1
1Division of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Medicina (Kaunas, Lithuania)
|April 26, 2025
概括
在亚洲亚组中,肺癌存活率差异很大. 在分析中对亚洲种族进行分类对于个性化治疗和公平的癌症护理至关重要.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 遗传学 遗传学 是一个
背景情况:
- 亚洲患者经常被不准确地分组,忽视了影响癌症结果的各种遗传和社会经济因素.
- 肺癌的生存是复杂的,涉及遗传学,环境和社会经济地位.
- 现有的研究往往无法区分不同的亚洲种族亚群.
研究的目的:
- 分析不同亚洲族裔亚组的第四阶段非小细胞肺癌 (NSCLC) 的生存结果变化.
- 调查这些小组之间息治疗利用率的差异.
- 突出了解癌症差异的细粒度数据的需要.
主要方法:
- 2020年国家癌症数据库的回顾性分析.
- 包括23,747名患有第四阶段NSCLC的患者,分为九个亚洲亚组.
- 卡普兰-梅尔分析和多变量Cox/物流模型,用于生存和息护理结果.
主要成果:
- 在亚洲亚组中观察到生存结果和息治疗利用率的显著差异.
- 日本人,韩国人,太平洋岛民,菲律宾人和老人/洪人/柬埔寨人/泰国人患者的生存率比中国患者差.
- 息治疗的利用率有所不同,与中国患者相比,日本和太平洋岛屿患者更有可能接受息治疗.
结论:
- 在第四阶段NSCLC的亚洲亚组中存在生存和息护理差异.
- 在预后分析中对亚洲种族进行分类对于理解种族的影响至关重要.
- 认识到这些差异对于个性化治疗,资源分配和公平的癌症护理政策至关重要.
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