40 Hz tACS与痴呆症认知练习同时进行的认知和神经精神影响:一个随机,交叉,双盲,假冒控制的随机化研究
Maria Anabel Uehara1, Sumeet Kalia2, Mari Garcia Campuzano3
1Biomedical Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.
Medicina (Kaunas, Lithuania)
|April 26, 2025
概括
这项研究表明,40 Hz跨交替电流刺激 (tACS) 与认知炼相结合,可显著改善痴呆症患者的认知能力并减少神经精神症状. 这些认知益处持续了很长一段时间,突出了tACS作为潜在的非侵入性疗法.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 在40 Hz的跨交替电流刺激 (tACS) 显示了认知增强的希望.
- 关于将tACS与认知炼相结合的研究有限,特别是痴呆症的长期影响.
研究的目的:
- 研究40 Hz tACS与认知练习对痴呆症患者的认知,神经精神症状和抑郁症的影响.
- 为了评估这种联合干预的长期疗效,使用模拟控制的双盲交叉设计.
主要方法:
- 42名患有痴呆症的参与者接受了为期4周的干预,使用真实或假的40赫兹tACS与认知练习 (MindTriggers应用程序) 相结合.
- 使用了具有≥8周洗期的交叉设计.
- 主要结果:阿尔茨海默氏病评估量表-认知子量表 (ADAS-Cog);次要结果:蒙哥马利-阿斯伯格抑郁症评分量表 (MADRS) 和神经精神病 inventory问卷 (NPI-Q).
主要成果:
- 与认知炼一起的真实40 Hz tACS显著改善了治疗后的ADAS-Cog得分 (p=0.019),并在2-3个月后 (p=0.048) 显示了持续的认知改善.
- 真实和假的tACS都降低了NPI-Q的得分 (p=0.003,p=0.015).
- 真实的tACS显著改善了MADRS得分 (p=0.007),而假的tACS没有.
结论:
- 40 Hz tACS与认知炼相结合,是一种有效的非侵入性干预,用于改善认知功能,神经精神病症状和痴呆症抑郁症.
- 这项研究表明,这种综合方法具有持续的认知益处.
- 这种干预有可能成为治疗痴呆症的治疗选择.
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