癌症患者进行皮肤冠状动脉干预的多血管冠状动脉疾病:系统性审查和元分析
Konstantinos C Siaravas1, Michail I Papafaklis2, Amalia I Moula3
1First Cardiology Department, University Hospital of Ioannina, 45500 Ioannina, Greece.
Life (Basel, Switzerland)
|April 26, 2025
概括
经过皮肤冠状动脉干预 (PCI) 的癌症患者与非癌症患者相比,冠状动脉多血管疾病 (MVD) 的发病率并不高. 这一系统性审查没有发现MVD率的显著差异,表明冠状动脉疾病负担相似.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 癌症患者因化疗和放射治疗等治疗而面临心血管风险增加.
- 了解癌症患者的冠状动脉疾病 (CAD) 模式对于控制心脏毒性至关重要.
研究的目的:
- 确定癌症患者中多血管冠状动脉疾病 (MVD) 与接受皮肤冠状动脉干预 (PCI) 的非癌症患者的比例.
- 通过系统性审查和元分析,通过系统性审查和元分析,比较这两组患者中MVD的患病率.
主要方法:
- 对观察性研究进行系统的文献选,比较PCI接受的癌症和非癌症患者的MVD发病率.
- 对来自17项研究的数据进行了元分析,其中包括5200名癌症患者和55146名对照患者.
- 对匹配的对照组,急性冠状动脉综合征患者,放射治疗接受者和活跃癌症患者进行了亚组分析.
主要成果:
- 在癌症患者和非癌症患者之间没有观察到MVD发生率的统计学上显著差异 (风险比:1.03;95%CI:0.99-1.08;p=0.19).
- 在研究中发现了很高的异质性 (I2=57.32%),但小组分析 (匹配对照,活跃癌症) 没有改变主要发现.
- 对急性冠状动脉综合征和放射治疗的亚组分析也显示MVD率没有显著差异.
结论:
- 多血管冠状动脉疾病 (MVD) 的发生率在癌症患者和接受皮肤冠状动脉干预 (PCI) 的非癌症患者中是相似的.
- 需要进一步的研究来阐明冠状动脉疾病在癌症患者群体中的特定特征.
- 目前的证据表明,单独诊断癌症并不能显著增加PCI患者的MVD患病率.
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