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在儿科囊性纤维化中探索嗅觉和ChiPSO

Tiana M Saak¹, Jeremy P Tervo¹, Brandon M Moore¹

¹Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.

Journal of clinical medicine

|April 26, 2025

概括

嗅觉功能障碍在患有囊性纤维化 (CwCF) 的儿童中很常见. 儿童嗅觉的个人重要性 (ChiPSO) 调查问卷显示,在CwCF中,嗅觉功能的重要性随着嗅觉功能的增加而增加.

科学领域:

医学研究医学研究
儿科卫生健康儿科卫生健康
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

嗅觉功能障碍 (OD) 是患有囊性纤维化 (PwCF) 患者的普遍症状,影响安全,营养和生活质量.
在PwCF中,OD被认为随着年龄的增长而恶化,通常与鼻腔疾病有关.
患有囊性纤维化 (CwCF) 的儿童的OD由于儿科嗅觉测试的挑战而未得到充分研究.

研究的目的:

评估儿童嗅觉个人意义 (ChiPSO) 问卷在CwCF.CF种族多样化的队列中的有用性.
评估CwCF中嗅觉功能,嗅觉的感知重要性和人口因素之间的关系.

主要方法:

一项试点研究涉及7至17岁的CwCF,他们完成了ChiPSO和关于嗅觉功能障碍 (bQOD-NS) 的简短问卷.
使用U-Sniff识别测试进行心理嗅觉评估.
包括相关性和回归在内的统计分析,以检查问卷分数,嗅觉性能和临床数据之间的关联.

主要成果:

在U-Sniff识别得分和整体ChiPSO总得分 (p=0.010) 以及其环境子域 (p<0.001) 之间发现了正相关性.
嗅觉表现和ChiPSO的食物或社会子域,或bQOD-NS得分之间没有明显的相关性.
西班牙裔种族与更高的ChiPSO分数相关 (p=0.041).

结论:

嗅觉的重要性,特别是对于环境刺激,随着CwCF中的嗅觉功能增加.
在CwCF中,ChiPSO问卷显示出对评估嗅觉感知有希望的结果.
研究结果表明,CwCF.的进展性疾病可能会影响嗅觉重要性的发展.

关键词:

这就是ChiPSO.孩子们的孩子们的孩子们的孩子们.囊性纤维化症是什么嗅觉嗅觉是一种嗅觉.嗅觉的重要性.人们的生活质量.

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