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形态测量胚胎细胞评估:一项回顾性研究,检查胚胎细胞直径和面积与辅助生殖技术周期中的妊娠结果之间的关系

Romualdo Sciorio^1,2, Pier Francesco Greco³, Luca Tramontano⁴

¹Fertility Medicine and Gynaecological Endocrinology Unit, Department Woman Mother Child, Lausanne University Hospital, 1011 Lausanne, Switzerland.

Journal of clinical medicine

|April 26, 2025

概括

用面积和直径来衡量胚芽细胞大小,可以显著预测辅助生殖技术 (ART) 中的怀孕成功. 较大的胚芽细胞与更高的植入率和持续妊娠率相关,有助于胚胎选择.

科学领域:

生殖生物学生殖生物学
胚胎学胚胎学
辅助生殖技术 (ART) 是一种助孕技术.

背景情况:

在ART中成功怀孕取决于优化胚胎培养和选择可行的胚胎.
预测植入潜力对于改善ART结果至关重要.
胚胎囊的形态测量分析为胚胎评估提供了客观的措施.

研究的目的:

在ART中调查胚胎囊面积和直径以及怀孕结果之间的相关性.
为了确定胚胎细胞形态学是否可以预测植入和正在进行的怀孕率.
评估在胚胎选择中客观胚胎囊测量的实用性.

主要方法:

对665名接受ART治疗的患者进行回顾性分析,在第5天进行单个胚胎囊移植.
测量胚胎囊面积 (μm2) 和直径 (μm).
统计分析以将形态特征与植入率 (IR) 和正在进行的临床怀孕率 (CPR) 相关联.

主要成果:

囊胞面积 (≥25,000微米2) 和直径 (≥170微米) 都与更高的IR和CPR显著相关.
与较小的胚胎相比,具有较大面积的胚胎显示出显著更高的IR (69.8%) 和CPR (65.5%),IR: 47.9%,CPR: 45.9%).
大直径的胚胎显示显著更高的IR (68.8%) 和CPR (66.3%) 与较小的胚胎相比 (IR: 36.6%,CPR: 35.7%).

结论:

胚胎细胞形态学变量 (面积和直径) 是胚胎生存能力的客观和可靠预测因素.
这些测量可以帮助胚胎学家选择具有更高植入潜力的胚胎.
客观的胚胎囊评估可以提高正在进行的怀孕成功率在ART.

关键词:

人工智能的人工智能是人工智能.胚胎囊的区域区域.胚胎囊的直径为临床怀孕的结果.深度学习是一种深度学习.在胚胎培养过程中,胚胎植入率的植入率是什么形态测量质囊细胞评估单个胚胎囊的转移

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