Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

177
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
177
Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

168
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
168
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

148
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
148
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

331
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
331
Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

175
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
175
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

372
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
372

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pulsed-Closure Assisted Continuous Atmospheric Pressure Interface for Miniature Ion Trap Mass Spectrometry with Enhanced Resolution and Sensitivity.

Journal of the American Society for Mass Spectrometry·2026
Same author

Comprehensive Evaluation of a Mucoadhesive Self-Emulsifying Anhydrous Base for Vaginal Drug Delivery.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Mastering particle size analysis: lessons, challenges, and future directions from the FDA-CRCG workshop.

AAPS open·2026
Same author

Time-resolved thermal desorption miniature ion trap mass spectrometry for rapid and simultaneous quantification of multiple cooling agents in complex matrices.

Analytical methods : advancing methods and applications·2025
Same author

Single-dose pharmacokinetics of sublingual semaglutide in rats.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos.

Transgenic research·2025

相关实验视频

Updated: May 10, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.1K

在体外通过皮肤吸收透增强雌激素配方.

Guiyun Song1, Kendice Ip1, Bruce Biundo1

  • 1Professional Compounding Centers of America (PCCA), 9901 South Wilcrest Drive, Houston, TX 77099, USA.

Pharmaceuticals (Basel, Switzerland)
|April 26, 2025
PubMed
概括

复合性雌激醇配方为激素替代疗法 (HRT) 提供稳定的皮肤吸收. 这些制剂提供了一致的荷尔蒙输送,与商业凝不同,这些凝的峰值和下降速度很快.

关键词:
雌二醇是雌二醇的一种药物.随时复合的配方是随时复合的配方.透增强剂是一种透增强剂.半固体制剂 半固体制剂皮肤 皮肤 皮肤专题 局部 局部 局部 局部通过皮肤通过皮肤.

更多相关视频

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

2.7K
Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory
14:13

Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory

Published on: January 1, 2018

13.0K

相关实验视频

Last Updated: May 10, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.1K
Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

2.7K
Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory
14:13

Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory

Published on: January 1, 2018

13.0K

科学领域:

  • 皮肤病学和制药科学 皮肤病学和制药科学
  • 内分泌学和荷尔蒙疗法治疗

背景情况:

  • 激素替代疗法 (HRT) 对于治疗女性激素缺陷至关重要.
  • 口服雌激素 (雌激醇[E2]和雌激醇[E3]) 可以引起副作用.
  • 局部雌激素应用提供了一个替代的输送途径,以改善患者的治疗结果.

研究的目的:

  • 为了评估复合性雌激醇和双雌激素配方的体外皮吸收.
  • 为了比较复合局部雌激素的吸收概况与商用雌激醇透皮凝 (ESTROGel®).

主要方法:

  • 使用经过验证的体外透试验 (IVPT) 来评估皮肤吸收.
  • 使用超高性能液态染色学 (UPLC) 分析了五种测试配方中的雌激醇和雌醇度.

主要成果:

  • ESTROGel®显示出迅速的初始雌激素吸收,在0.5小时内达到峰值,随后迅速下降.
  • 复合配方显示,雌醇吸收的缓慢,稳步增加,在6小时内达到峰值流量.
  • 所有测试的复合配方在16小时内都保持了稳定的雌激素吸收.

结论:

  • 复合基促进了持续的皮肤间雌激素吸收,避免了HRT所需的快速流量变化.
  • 雌激素化合物配方是局部激素输送的可行选择.
  • 复合药剂师和医疗保健提供者可以考虑这些配方用于患者激素治疗.