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维生素D与认知障碍的关系
Nalinee Imerbsin1,2, Prapimporn Chattranukulchai Shantavasinkul3,4, Pirada Witoonpanich5
1Doctor of Philosophy Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok 10400, Thailand.
Nutrients
|April 26, 2025
概括
维生素D不足在泰国老年人中很常见. 虽然低维生素D与肥胖和胰岛素抵抗有关,但它似乎不会直接影响这一群体的认知功能.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏是一个公共卫生问题,也是轻度认知障碍 (MCI) 的潜在危险因素.
- 现有的关于维生素D状态和认知功能的证据是相互矛盾的.
- 这项研究调查了泰国老年人的维生素D状况,重点关注其与认知功能,脂肪和胰岛素敏感性的关系.
研究的目的:
- 为了确定泰国老年人中维生素D缺乏症的患病率.
- 检查维生素D状态与认知功能之间的关联.
- 在这个人群中探索维生素D状态,脂肪和胰岛素敏感性之间的关系.
主要方法:
- 这项研究包括来自HADThai研究队列的718名55-80岁的参与者.
- 参与者被分为正常认知功能或轻度认知障碍 (MCI) 组.
- 分析了基线数据,以评估维生素D水平,认知功能,身体组成 (BMI,体脂) 和胰岛素抵抗 (HOMA-IR).
主要成果:
- 在正常认知和MCI组之间,维生素D状态没有显著差异.
- 维生素D缺乏 (<20 ng/mL) 的患病率为6.5%,不足 (<30 ng/mL) 的患病率为40.0%.
- 血清25(OH) D度与BMI,身体脂肪和HOMA-IR呈反向关联,但与认知功能无关.
结论:
- 在泰国老年人群中观察到维生素D缺乏的高患病率.
- 维生素D状态与脂肪和胰岛素抵抗相反相关.
- 这项研究不支持维生素D状态在老年人群认知衰退中的直接作用,但需要进一步的研究.
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