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葡萄酒消费和肺癌风险:系统性审查和元分析

Carlotta Bertola¹, Camilla Gobbetti¹, Gaia Baccarini¹

¹Section of Hygiene and Public Health, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.

|April 26, 2025

概括

这次元分析发现,葡萄酒消费与肺癌总体风险之间没有显著的联系. 然而,在吸烟者中观察到一种潜在的保护作用,尽管这一发现需要进一步调查.

科学领域:

在瘤学瘤学.
流行病学流行病学
营养科学营养科学

背景情况:

肺癌仍然是癌症死亡的主要原因,吸烟是主要的危险因素.
肺癌患者中很大一部分是非吸烟者,这凸显了其他因素 (如酒精消费) 的作用.
乙醇是第一组致癌物,但葡萄酒中的多可能对健康有好处,这促使人们对其与肺癌的特定关联进行了调查.

研究的目的:

进行一项元分析,调查葡萄酒消费与肺癌风险之间的相关性.
根据吸烟状态和性别来分层风险.
为了比较沉重的葡萄酒消费者和非常偶尔的饮酒者.

主要方法:

在PubMed,Scopus和Web of Science数据库中进行系统的文献审查.
随机效应元分析比较最高和最低的葡萄酒消费类别.
使用纽卡斯尔-太华尺度 (NOS) 进行偏差风险评估;使用ProMeta 3.0软件进行统计分析.

主要成果:

总体而言,葡萄酒消费显示,肺癌风险降低了11% (OR = 0.89),但不显著.
在吸烟者中,葡萄酒消费与肺癌风险显著降低22%有关 (OR = 0.78).
当分析按研究设计分层时,在吸烟者中没有一致观察到这种显著效应.

结论:

葡萄酒消费与肺癌发病率之间没有明确的相关性,既没有保护性,也没有增加风险.
需要进一步的研究来准确评估这种关系,特别是在非吸烟者群体中.

关键词:

肺癌是一种肺癌.这是一个元分析.葡萄酒的消费葡萄酒的消费葡萄酒的摄入量葡萄酒的摄入量

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