在糖尿病前期和糖尿病中改变生活方式:大量人口分析
Michael L Dansinger1, Joi A Gleason1, Julia Maddalena1
1Boston Heart Diagnostics Corporation, 200 Crossing Boulevard, Framingham, MA 01702, USA.
Nutrients
|April 26, 2025
概括
数字生活方式计划有效地降低了糖尿病前期患者的糖尿病风险,并改善了糖尿病患者的缓解率. 这种干预措施对动脉样硬化心血管疾病风险因素和代谢标志物产生了积极的影响.
科学领域:
- 内分泌学和新陈代谢学
- 预防心血管疾病 预防心血管疾病
- 公共卫生和生活方式干预措施
背景情况:
- 糖尿病是动脉样硬化心血管疾病 (ASCVD) 的主要驱动因素.
- 糖尿病前期和糖尿病显著提高ASCVD风险因素.
- 生活方式干预对于管理糖尿病及其并发症至关重要.
研究的目的:
- 评估自愿生活方式计划在糖尿病前和糖尿病患者群体中的有效性.
- 评估一个由营养学家指导的数字节目对糖尿病风险和代谢标志物的影响.
- 分析与生活方式改变相关的心血管风险因素的变化.
主要方法:
- 对包括健康,糖尿病前期和糖尿病患者在内的大量队列 (133,764名受试者) 的分析.
- 测量主要的代谢和心血管风险标志物:葡萄糖,胰岛素,HbA1c,脂质 (包括sdLDL-C),hs-CRP等.
- 对参与数字生活方式修改计划的参与者的后续评估,计算10年糖尿病风险.
主要成果:
- 糖尿病前患者和糖尿病患者表现出高甘油,sdLDL-C,hs-CRP和降低的HDL-C,表明胰岛素耐药性.
- 生活方式的改变使得糖尿病前期患者的糖尿病风险降低了45.6%,糖尿病缓解率增加了2.4倍 (8.2%对3.4%).
- 干预导致了显著的体重减轻和多种代谢标志物的有利变化.
结论:
- 禁食葡萄糖和胰岛素测量对于识别糖尿病患者胰岛素产量下降至关重要.
- 一个数字生活方式计划证明了ASCVD风险因素和糖尿病状况的显著好处.
- 生活方式干预是有效的缓解糖尿病的进展和改善代谢健康.
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