在糖尿病病症中,异构系数,预后营养指数和各种肥胖指数之间的潜在关联
Mohamed-Zakaria Assani1,2, Marius Bogdan Novac3, Anda Lorena Dijmărescu4
1Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Nutrients
|April 26, 2025
概括
动脉生成系数 (AC) 和预后营养指数 (PNI) 可能有助于评估2型糖尿病 (T2DM) 的营养和炎症状况. 较高的AC和较低的PNI与并发症相关,这表明早期评估有助于预测糖尿病病.
科学领域:
- 内分泌学和新陈代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题,经常与慢性病 (CKD) 和代谢障碍同时发生.
- 像内脏脂肪指数 (VAI) 和体脂肪指数 (BAI) 这样的肥胖指数与糖尿病患者的心血管和脏问题有关.
- 有限的研究整合了动脉动脉系数 (AC) 和预后营养指数 (PNI) 来评估糖尿病病 (DN).
研究的目的:
- 评估T2DM和糖尿病前期 (PreDM) 患者与肥胖相关指数和免疫/营养因素之间的关联.
- 研究AC和PNI作为糖尿病患者生物标志物的实用性.
主要方法:
- 在6个月内对268名T2DM和150名PreDM患者进行了回顾性,横截面研究.
- 收集的人类测量,实验室和人口统计数据.
- 计算了AC和PNI;进行了统计分析以与代谢和炎症标志物相关联.
主要成果:
- 与PreDM患者相比,T2DM患者表现出明显较低的PNI (表明营养不良) 和较高的AC.
- 升高的AC与脂质形状变化和全身炎症相关.
- 肥胖指数,特别是VAI,在T2DM患者中较高,AC升高,在AC亚组中显示胆固醇,LDL-c和甘油三的显著差异.
结论:
- 在糖尿病患者中,AC和PNI显示出作为营养,炎症和脂质状况的生物标志物的潜力.
- 早期评估肥胖指数,AC,PNI和脂质概况可能有助于预测糖尿病并发症,包括DN.
- 需要进一步的研究来探索AC和PNI在管理T2DM和CKD进展方面的临床实用性,以及脂质配置如何影响DN进展.
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