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oesophageal状细胞癌的独特微生物特征基于光梯度增强机器学习分类器的不同饮食习惯的患者

Shun Liu¹, Zhifeng Lin¹, Zhimin Huang¹

¹Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

|April 26, 2025

概括

饮食习惯显著改变肠道状细胞癌 (ESCC) 患者的肠道微生物群,影响特定的细菌,如Eubacterium_B sulci和Fusobacterium_C,以及它们相关的代谢功能.

科学领域:

微生物学微生物学
在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

人类微生物群因其在癌症发展和进展中的作用而越来越受认可.
在食道状细胞癌 (ESCC) 中,饮食模式和食道微生物群之间的特定相互作用仍然不太清楚.

研究的目的:

研究ESCC患者的饮食习惯与食道微生物群组成和功能之间的复杂关系.
在这个患者队列中,确定与不同饮食模式相关的特定微生物和功能变化.

主要方法:

16S rRNA测序用于分析173名ESCC患者的微生物多样性和组成.
使用LefSe,Boruta和LightGBM算法进行微生物查和与饮食习惯的关联.
PICRUST2和DESeq2预测了微生物的功能,而相关性和网络分析则探索了微生物的功能和微生物与微生物的相互作用.

主要成果:

在不同饮食习惯的ESCC患者中观察到微生物组成的显著变化.
特定的细菌,包括Eubacterium_B sulci和未定义的 (Fusobacterium_C),被确定与特定的饮食群体有显著的关联.
不同的代谢途径差异丰富,Eubacterium_B sulci和未定义的 (Fusobacterium_C) 显示与特定途径的正相关性.

结论:

饮食习惯明显影响食道微生物组合和ESCC中的功能.
在Eubacterium_B sulci和未定义 (Fusobacterium_C) 丰度及其相关代谢途径的变化与ESCC的特定饮食模式有关.

关键词:

轻GBMM 轻GBMM 的时间饮食饮食饮食饮食微生物是一种微生物.消化管皮细胞癌的癌症.

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