从Cyclosorus terminans中提取的中断素保护大鼠高脂肪饮食引起的肠道病理
Chanisa Thonusin1,2,3, Kanokphong Suparan2,3, Chanon Kunasol2,3
1Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Nutrients
|April 26, 2025
概括
在食高脂肪饮食的老鼠中,Cyclosorus terminans提取物减轻了体重,改善了肠道健康. 这种类动物对预防饮食诱导的肠道炎症和失生症充满希望.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- Cyclosorus terminans (C. terminans),也被称为少女,含有中断A和B.
- 之前的研究表明,C. terminans可能有助于治疗肥胖,胰岛素抵抗和脂肪肝.
- 菌对肠道健康的影响,特别是在高脂肪饮食的背景下,以前是未知的.
研究的目的:
- 研究C.terminans提取物对肠道功能障碍的保护作用.
- 评估C. terminans在食用高脂肪/高卡路里饮食的老鼠中的疗效.
主要方法:
- 雄性Wistar大鼠被分为四组:正常饮食与载体,高脂肪/高卡路里饮食与载体,高脂肪/高卡路里饮食与100毫克/千克/天C. terminans提取物,高脂肪/高卡路里饮食与200毫克/千克/天C. terminans提取物.
- 大鼠接受了12周的治疗.
- 在治疗期后收集便和结肠组织进行分析.
主要成果:
- 100和200毫克/公斤/天的C.terminans提取物相比于车辆对照组,显著减少了体重增加.
- 提取物改善了肠道炎症和肠道屏障破坏.
- C. terminans治疗使短链脂肪酸水平正常化,并逆转由高脂肪/高卡路里饮食引起的肠道失调症.
结论:
- 在高脂肪/高卡路里饮食的老鼠中,C. terminans提取物有效地减弱了体重增加.
- 提取物证明了对肠道病理的预防作用,包括炎症,屏障破坏和与高脂肪/热量摄入相关的失生症.
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