早期营养干预非小细胞肺癌患者同时接受化学放射治疗:第二阶段前性研究
Fangjie Liu1,2, Qiaoting Luo1, Yu Xi3
1Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Nutrients
|April 26, 2025
概括
在接受化疗放射治疗的局部晚期非小细胞肺癌患者的早期营养干预改善了营养状况,减少了辐射性肺炎. 这种干预也导致了更长的无进展生存期.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 当地晚期非小细胞肺癌 (LANSCLC) 患者接受并发化疗放射治疗 (CCRT) 经常出现营养不良和与治疗相关的毒性.
- 早期营养干预策略对于改善这些患者的治疗结果至关重要.
研究的目的:
- 评估早期营养干预对接受CCRT的LANSCLC患者营养状况和生存率的影响.
- 评估减肥和其他临床结果的发生率.
主要方法:
- 一项II期研究,涉及接受CCRT的LANSCLC患者.
- 研究小组在CCRT期间和之后接受了个性化的营养咨询和口服营养补充剂.
- 从以前的试验中匹配的对照组被用于通过倾向性得分匹配进行比较.
主要成果:
- 与对照组相比,干预组的体重减轻发病率较低 (≥5%),体重指数较高,前白蛋白水平有所改善.
- 观察到患者生成的主观全球评估得分降低和2级+辐射肺炎的发病率降低.
- 在干预组中,无进展的生存时间明显更长 (13.5个月与11.3个月).
结论:
- 在接受CCRT的LANSCLC患者的早期营养干预可以改善营养状况并减轻辐射性肺炎.
- 肠道微生物群的组成,特别是Firmicutes/Bacteroidetes比率,与口服营养补充剂的反应有关.
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