揭示口服药物输送的三维打印技术进步:应用于中枢神经系统相关疾病的应用
Samir I Paipa-Jabre-Cantu1, Marisela Rodriguez-Salvador1, Pedro F Castillo-Valdez1
1Tecnologico de Monterrey, Monterrey 64700, Nuevo León, Mexico.
Pharmaceutics
|April 26, 2025
概括
三维 (3D) 打印为中枢神经系统 (CNS) 疾病提供了创新的口服药物输送解决方案. 这项技术使得针对神经系统疾病的个人化医疗具有精确的剂量和受控释放.
科学领域:
- 制药技术 制药技术 制药技术
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 中枢神经系统 (CNS) 疾病对全球健康构成重大挑战,需要先进的药物输送解决方案.
- 三维 (3D) 打印技术为开发具有增强功能的定制口服药物提供了创新的机会.
- 缺乏对3D打印在中枢神经系统口服药物输送方面的进展进行全面分析.
研究的目的:
- 在中枢神经系统疾病中进行3D打印用于口服药物输送的技术景观分析.
- 确定这个快速发展的领域的关键进展,挑战和未来方向.
主要方法:
- 采用了竞争性技术情报 (CTI) 方法.
- 从Scopus数据库中分析了747个出版物 (2019年1月至2024年5月).
主要成果:
- 沉积建模 (FDM) 是用于制药应用的主要3D打印技术.
- 关键的进步包括多种剂型 (药片,多种药片,薄膜),热塑性聚合物 (PLA,PVA,PCL) 的使用,新的释放模式设计以及针对患者的定制剂量.
- 关键质量方面侧重于精确的活性药物成分 (API) 剂量和中枢神经系统药物的受控释放机制.
结论:
- 3D打印的进步为改善中枢神经系统疾病的口服药物输送提供了显著的潜力.
- 这项技术可以实现个性化医疗,精确的剂量和受控释放,解决神经病患者的关键需求.
- 研究结果为研究人员,学者和决策者提供了宝贵的见解,以促进中枢神经系统药物输送方面的创新.
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