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Updated: May 10, 2025

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
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Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

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新型人工5'UTR增加修改后的mRNA翻译,当注入到老鼠的心脏时

Ann Anu Kurian1,2,3, Matteo Ghiringhelli1,2,3, Eyal Shalom1,2,3

  • 1Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Pharmaceutics
|April 26, 2025
PubMed
概括

研究人员开发了一种名为"顶部心脏5'UTR"的新型人工5'未翻译区域 (5'UTR),以促进心脏细胞中修饰的信使RNA (modRNA) 的翻译. 这项创新增强了潜在的心脏治疗的基因传递.

关键词:
5′未翻译的区域心脏基因治疗的心脏基因治疗修饰RNA (modRNA) 是一种修饰RNA.合成RNA基因的合成RNA基因.翻译效率 翻译效率 翻译效率

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