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Updated: May 10, 2025

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在目标蛋白质降解中克服物理化学性质和生理障碍的PROTAC交付策略

Endry Wahyu Syahputra1, Hyunji Lee2, Hyukjun Cho1

  • 1College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea.

Pharmaceutics
|April 26, 2025
PubMed
概括

针对蛋白质分解的嵌合体 (PROTACs) 面临着交付方面的挑战. 专用配方显著提高了PROTAC的生物可用性和疗效,改善了临床前模型中的治疗结果.

关键词:
这就是PROTAC.生物可用性 生物可用性药物输送系统是药物输送系统.物理化学属性 物理化学属性溶化溶解化 溶解化

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