皮克林双乳液稳定与奇纳米晶和神秘酸功能化纳米颗粒的库尔库和基酸联合交付
Javier Paredes-Toledo1, Javier Herrera1, Javier Morales2
1Department of Food Science and Technology, Faculty of Technology, University of Santiago of Chile, Av. Víctor Jara 3769, Estación Central, Santiago 9170124, Chile.
Pharmaceutics
|April 26, 2025
概括
奇纳米晶和功能化纳米颗粒产生稳定的皮克林双乳液,同时释放水溶和油溶化合物. 这些皮克林乳液显示出在消化过程中提供生物活性成分的潜力.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 双乳液 (DEs) 提供水和油溶性化合物的同时封装.
- 使用固体颗粒的皮克林稳定增强了DE的稳定性,在接口上形成了硬质屏障.
- 基纳米晶 (ChNCs) 和功能化纳米粒子 (SNPs-C14) 被探索为稳定DE.
研究的目的:
- 为了评估黄素和原酸 (CA) 在皮克林DES在体外胃肠道消化下释放的行为.
- 评估CHNC和SNP-C14对DE稳定性和生物活性化合物释放的影响.
- 为了比较皮克林DE与传统DE中的封装化合物的生物可访问性.
主要方法:
- 统计设计以优化CNC稳定的一致化.
- 皮克林DES的特征:滴滴大小,微观结构,制,封装效率,质.
- 使用INFOGEST方法进行体外胃肠道消化.
主要成果:
- NC提高了DE的物理稳定性,防止凝聚和化.
- 由于内部接口稳定,DE-ChNC-C14显示出更高的CA封装效率 (91.4%),而不是DE-ChNC (45.0%).
- 由于脂质消化减少,CA的生物可访问性与对照DEs相似 (~60%),而黄素的生物可访问性较低 (~40%).
结论:
- ChNCs和SNP-C14有效地稳定了DE的内部和外部接口.
- 皮克林DES使水和油溶性生物活性物同时释放.
- 开发的Pickering DEs提供了一个有前途的系统,用于提供具有健康益处的生物活性化合物.
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