Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.1K
Overview
65.1K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

260
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
260

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

ScopeViewer: a browser-based solution for visualizing large biological images.

GigaScience·2026
Same author

Oligonucleotide genetics for <i>Pseudomonas aeruginosa</i> enables high throughput hypomorph screening.

bioRxiv : the preprint server for biology·2026
Same author

An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans.

Nature communications·2026
Same author

A microbiota-derived bile acid overcomes antibiotic-induced hyporesponsiveness to immune checkpoint therapy by enhancing CD8 <sup>+</sup> T cell antitumor immunity.

bioRxiv : the preprint server for biology·2026
Same author

Gut Microbiome Composition and Variance Are Modified by Degree of Growth Failure in Preterm Infants: A Prospective Study.

Nutrients·2025
Same author

Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis.

bioRxiv : the preprint server for biology·2025

相关实验视频

Updated: May 8, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

7.7K

优化精密益生菌以缓解移植对宿主疾病的疾病.

Nonyelum Ebigbo1, Apple Long2, Phinga Do1

  • 1Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Microorganisms
|April 26, 2025
PubMed
概括

通过选择特定的细菌菌株来优化精确益生菌,在临床前模型中显著改善了移植与宿主疾病 (GVHD) 的结果. 这种有针对性的方法增强了短链脂肪酸的生产,提高了生存率.

关键词:
精确益生菌 精确益生菌益生菌是一种益生菌.短链脂肪酸 短链脂肪酸

更多相关视频

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

9.5K
Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
12:12

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

12.3K

相关实验视频

Last Updated: May 8, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

7.7K
Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

9.5K
Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
12:12

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

12.3K

科学领域:

  • 微生物学 微生物学
  • 免疫学 免疫学 免疫学
  • 胃肠病学 胃肠病学

背景情况:

  • 精密益生菌具有治疗潜力,但由于特定菌株的变异而面临挑战.
  • 移植与宿主疾病 (GVHD) 是异种干细胞移植后的一种严重的自身免疫并发症.

研究的目的:

  • 在临床前模型中优化和验证GVHD的六种精密益生菌疗法.
  • 调查关键肠道微生物群物种中短链脂肪酸 (SCFA) 生产的菌株变异性.

主要方法:

  • *B. longum*, *C. bolteae* 和 *Blautia* spp. 的孤立和特征化菌株. 来自人类干细胞移植患者.
  • 在实验室中评估了SCFA生产和共同培养相互作用.
  • 在GVHD.的小鼠模型中比较"优化"与"标准"益生菌联盟的疗效.

主要成果:

  • 在SCFA生产中观察到显著的菌株间变异性.
  • *B. longum*在共同培养中增加了*C. bolteae*和*Blautia*的乳酪酸盐产量.
  • 与标准益生菌相比,优化的益生菌减轻了GVHD,增加了存活率 (p=0.013),并增加了肠道SCFA (p<0.001).

结论:

  • 菌株选择对于最大限度地提高精密益生菌的治疗效果至关重要.
  • 一种优化的精确益生菌方法显示出对管理GVHD和潜在的其他炎症状况的承诺.