相关实验视频

Updated: May 10, 2025

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

开发和验证早期预警模型,用于糖尿病 - 结核病并发症

Zhaoyang Ye^1,2,3, Guangliang Bai⁴, Ling Yang²

¹Institute of Tuberculosis, Senior Department of Tuberculosis, The Eighth Medical Center of PLA General Hospital, Beijing 100091, China.

|April 26, 2025

概括

这项研究确定了三个关键的免疫生物标志物CETP,TYROBP和SECTM1用于早期预测糖尿病 (DM) 和结核病 (TB) 共感染 (DM-TB). 一个经过验证的风险模型有助于对这一复杂的全球健康挑战进行早期查.

科学领域:

免疫学免疫学免疫学
基因组学就是基因组学.
计算生物学计算生物学

背景情况:

糖尿病 (DM) 增加了对结核病 (TB) 的易感性,造成了重大的全球健康负担 (DM-TB).
目前缺乏对DM-TB的早期风险预测,这阻碍了及时干预和管理.
确定强大的生物标志物对于开发有效的查策略至关重要.

研究的目的:

确定与免疫相关的生物标志物,用于早期预测糖尿病和结核病 (DM-TB) 患者的风险.
使用已识别的生物标志物构建和验证DM-TB的预测模型.
分析DM-TB患者的免疫状态和潜在的致病机制.

主要方法:

从GEO数据库 (GSE181143,GSE114192) 挖掘DM-TB患者的转录组数据.
差异基因表达分析,权重基因共同表达网络分析 (WGCNA) 和机器学习算法.
使用前性队列研究,RT-qPCR,免疫透的CIBERSORT和KEGG通路分析进行验证.

主要成果:

鉴定了与DM-TB相关的1090个差异表达基因 (DEGs).
确定CETP,TYROBP和SECTM1作为具有高预测准确度的关键免疫生物标志物 (AUC从0.804到0.811不等).
开发一种具有显著预测效率的早期预警模型 (AUC = 0.86,外部验证为AUC = 0.901),揭示了改变的免疫细胞透和关键信号通路 (NF-κB,MAPK).

结论:

CETP,TYROBP和SECTM1是早期DM-TB风险评估的有希望的免疫生物标志物.
开发的风险模型为DM-TB提供了潜在的早期查策略.
了解DM-TB中的免疫调节障碍,可以了解致病机制和潜在的治疗点.

关键词:

在糖尿病中,糖尿病是血糖类的.早期预警模式的早期预警模式与免疫相关的生物标志物.机器学习是机器学习.结核病是一种肺结核病.

更多相关视频

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

相关概念视频

Diabetes: Symptoms, Diagnosis, and Complications

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...