切莱里对Xanthomonas oryzae的抗菌作用和机制 pv. 里扎伊 在线观看
Yi Yan1,2, Jueyu Wang1,2, Na Zhao1,2
1College of Life Science, Northeast Forestry University, Harbin 150040, China.
Microorganisms
|April 26, 2025
概括
切利利思林是一种植物性化合物,有效地抑制了Xanthomonas oryzae pv. (Xoo) 的生长和致病性. 这种天然抗菌剂破坏细菌细胞分裂,膜完整性和新陈代谢,提供了一种有前途的新策略来对抗细菌病变.
科学领域:
- 植物生物化学 植物生物化学
- 微生物学 微生物学
- 细菌学 细菌学是一门学科.
背景情况:
- 克桑托莫纳斯里扎 (Xanthomonas oryzae pv.) 是一个植物. 菌 (Xoo) 由于细菌病害,导致全球农作物大幅损失.
- 现有的治疗方法面临着耐药性和环境影响的挑战.
- 植物衍生化合物为新的抗微生物战略提供了潜力.
研究的目的:
- 调查切莱利林对Xoo的抗菌作用.
- 为了阐明切莱里思林对Xoo的作用机制.
主要方法:
- 确定了对Xoo.的切莱里的最小抑制度 (MIC).
- 评估了切莱里思林对Xoo细胞形态和分裂的影响.
- 分析了切莱里对Xoo细胞膜透性的影响,致病性因素 (细胞外多糖,细胞酶,生物膜),反应性氧物种 (ROS) 生产和关键代谢途径.
主要成果:
- 切莱里思林在1.25微克/毫升时显著抑制了Xoo的生长,诱导了丝状的生长.
- 它破坏了Xoo细胞膜的完整性,减少了病原性因素,并增加了ROS积累.
- 机制包括抑制Z环形成,核酸合成,DNA修复,糖和脂质A合成,以及干扰碳水化合物代谢.
结论:
- 切莱里在低度下表现出针对Xoo的多目标抗菌性质.
- 它破坏多种重要细菌过程的能力使其成为新型抗菌药物开发的有力候选者.
- 这些发现支持使用切莱里作为开发有效植物性抗菌素的基础,以对抗Xoo.
相关概念视频
01:18Indirect-Acting Cholinergic Agonists: Mechanism of Action
1.5K
Indirect-acting cholinergic agonists work by interacting with an enzyme called acetylcholinesterase (AChE) in the synaptic cleft. They can be reversible or irreversible inhibitors and have different effects on the enzyme.
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
1.5K
01:31Direct-Acting Cholinergic Agonists: Pharmacokinetics
976
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
976
01:29Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
473
Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
473
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
557
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
557
01:27Combined Effects of Drugs: Synergism
3.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.6K
01:29Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
2.0K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
2.0K