血液比率的诊断和预后价值在狗脏血栓肉瘤:一个多中心观测研究
Ana M Marques1, Gonçalo Petrucci2,3,4,5,6, Hugo Gregório4,5,6,7
1Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Veterinary sciences
|April 26, 2025
概括
完整的血细胞计数和特定的血液比率可以帮助诊断狗脏血栓肉瘤 (HSA). 增加中性粒细胞与红细胞的比率 (NRR) 和降低血小板与淋巴细胞的比率 (PLR) 与患有HSA的狗的预后有关.
科学领域:
- 兽医瘤学 兽医瘤学
- 血液学 血液学 血液学
- 狗癌症生物标志物 狗癌症生物标志物
背景情况:
- 周围全血细胞计数 (CBC) 和血液比率,如中性粒细胞与淋巴细胞比率 (NLR),中性粒细胞与红细胞比率 (NRR) 和血小板与淋巴细胞比率 (PLR) 在人类癌症诊断和预后中得到利用.
- 这些血液学参数的诊断和预后价值在狗膜血肉瘤 (HSA) 中尚未得到广泛的研究.
研究的目的:
- 评估CBC参数,NLR,NRR和PLR作为犬骨HSA的诊断和预后生物标志物的潜力.
- 确定这些血液学指数与无病区间 (DFI) 和脏HSA的狗的整体存活率 (OS) 的关联.
主要方法:
- 追溯分析了2018年至2022年间接受了脊髓切除术的154只狗的医疗记录.
- 在被诊断为脊髓HSA的狗 (n=63) 和其他脊髓病变的狗之间比较CBC参数,NLR,NRR和PLR.
- 多变量生存分析以确定DFI和OS的独立预后因素.
主要成果:
- 与其他脏病变相比,患有脏HSA的狗的中性粒细胞数量显著增加,NRR增加,血小板数量减少,PLR减少.
- 增加的NRR和减少的PLR与脊髓HSA的狗中复发和死亡的风险更高有关.
- 多变量分析确定NRR作为DFI的独立预后因素 (HR=1.837,p=0.011).
结论:
- NRR和PLR显示出作为犬骨HSA的诊断生物标志物的潜力.
- NRR和PLR可以作为有价值的预后指标,用于疾病复发和存活与脏HSA的狗.
- 建议进行进一步的验证研究,以证实NRR和PLR在治疗犬骨HSA中的有用性.
关键词:
在NLR中,它是NLR.这就是为什么NRR是NRR在PLR PLR中,血细胞计数是指血液中的细胞数量.癌症 癌症 癌症 癌症 癌症狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗脊髓瘤 脊髓瘤 脊髓瘤更多相关视频
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