认知障碍对抗高血压药物在艾滋病毒治疗中的影响
Azin Tavasoli1, Bin Tang2, Mohammadsobhan S Andalibi1
1Department of Neurosciences, University of California San Diego, San Diego, CA 92093, USA.
Viruses
|April 26, 2025
概括
艾滋病毒感染者 (PWH) 的认知表现恶化与抗高血压药物的使用增加相关. 处方者应避免在PWH中服用抗胆固醇药物,以减轻认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 与衰老相关的并发症在艾滋病毒感染者 (PWH) 中很普遍.
- 高血压 (HTN) 与认知能力下降有关,抗胆固醇抗高血压剂可能会使其恶化.
- 研究探讨了高血压PWH和没有艾滋病毒 (PWoH) 的人中神经认知表现和抗高血压剂之间的联系.
研究的目的:
- 为了研究神经认知表现和抗高血压药物的使用之间的关系,在高血压的个体和没有艾滋病毒.
- 为了确定是否增加抗高血压药物处方与随着时间的推移而恶化的神经认知功能相关.
- 检查抗高血压药物抗胆性质在PWH认知衰退中的作用.
主要方法:
- 在五年间进行了长度分析,包括七次访问 (1999-2022年).
- 纳入标准:报告的HTN或使用的抗高血压剂.
- 认知评估通过使用人口统计学纠正的T分数来评估全球绩效;通用线性混合效应模型分析了关联.
主要成果:
- 在PWH (p=0.012) 中与抗高血压剂增加相关的认知表现恶化,但在PWoH中没有 (p=0.58).
- PWH的平均动脉压 (MAP) 比PWoH (β = -5.05,p < 10−11) 低.
- 在PWH中,增加抗胆固醇药物的使用与随着时间的推移认知表现较差相关 (p < 0.001).
结论:
- 经历认知衰退的PWH被处方更多的抗高血压药物,可能是由于耐火性HTN或粘附性差.
- 对PWH的抗高血压处方做法需要仔细考虑.
- 建议在PWH治疗中避免使用具有抗胆性质的抗高血压药物.
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