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在健康人群中,E-鼻子衍生的呼吸印记的高一致性:一个横截面观测研究
Silvano Dragonieri1, Vitaliano Nicola Quaranta1, Andrea Portacci1
1Respiratory Diseases, University of Bari "Aldo Moro", 70121 Bari, Italy.
Sensors (Basel, Switzerland)
|April 26, 2025
概括
电子鼻子 (e-noses) 显示出对非侵入性诊断的前景. 这项研究在健康个体中发现了一致的呼吸痕迹,支持临床使用电子鼻子协议的标准化.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 电子鼻子 (e-noses) 为呼吸分析提供了一种非侵入性方法.
- 标准化的协议对于e-nose技术的临床实施至关重要.
- 呼吸痕迹的变化可能会阻碍诊断的准确性.
研究的目的:
- 用Cyranose 320 e-nose.评估健康受试者的呼吸痕迹的一致性.
- 提供支持临床诊断电子鼻子协议标准化的数据.
- 评估使用电子鼻子用于可靠的呼吸分析的可行性.
主要方法:
- 从139名健康的非吸烟成年人采集了呼吸样本,使用标准化协议.
- 赛拉诺斯320电子鼻子用于立即分析呼出的气息.
- 主要组件分析 (PCA) 和K-means集群被用于数据分析.
主要成果:
- PCA揭示了四个主要组成部分,占呼吸痕迹变异的97.15%.
- 通过K-means聚类,确定了两个组:一个异常值和138名具有高度一致的呼吸痕迹的受试者.
- 观察到的变化很低,从集群中心的中位距离为0.21.
结论:
- 在健康个体中呼吸痕迹的高一致性支持电子鼻子协议的标准化.
- 电子鼻子技术显示出临床诊断的巨大潜力.
- 需要在不同的人群和疾病群体中进行进一步的研究,以验证这些发现.
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