将基于生物膜的发酵与连续工艺相结合,以改善L-Valine生产

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Updated: May 10, 2025

Light-Controlled Fermentations for Microbial Chemical and Protein Production
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Light-Controlled Fermentations for Microbial Chemical and Protein Production

Published on: March 22, 2022

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Caice Liang1, Yong Wang1, Shuqi Shi1

  • 1National Engineering Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.

Biotechnology journal
|April 26, 2025
PubMed
概括

这项研究引入了一种基于生物膜的新型连续发酵 (BCF) 系统,用于持续生产L-氨酸. 与传统的自由细胞方法相比,BCF系统提高了L-氨酸的产量和纯度.

关键词:
埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.这是一种L-瓦林.基于生物膜的连续发酵.基于生物膜的固定发酵.自由细胞发酵的发酵过程.

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Fates of Pyruvate01:20

Fates of Pyruvate

Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
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