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网络药理学综合实验验证揭示了奎尔素作为Hedyotis diffusa抗BRCA的关键成分

Queting Chen¹, Yuanzhuang Xu^2,3, Jianhua Ma¹

¹Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, China.

Chemical biology & drug design

|April 26, 2025

概括

Quercetin 是 Hedyotis diffusa 的一个关键成分,显示出对抗乳腺癌 (BRCA) 的潜力. 这种传统中医 (TCM) 提取物及其活性化合物向参与癌症途径的关键基因.

科学领域:

植物化学植物化学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

花是一种传统中医药 (TCM),具有很长的临床使用历史.
它的抗瘤作用是公认的,但针对乳腺癌 (BRCA) 的特定成分和机制需要进一步阐明.

研究的目的:

调查Hedyotis diffusa对BRCA的活性成分和分子机制.
为了综合分析,将网络药理与实验验证相结合.

主要方法:

网络药理学确定素是核心成分,BIRC5,CDK1,FOS和HSP90AA1是关键目标.
凯格丰富分析突出了与癌症相关的途径 (例如PI3K-AKT信号传递).
在体外实验中验证了昆塞丁对乳腺癌细胞系 (MCF-7,MDA-MB-231) 的作用.

主要成果:

Quercetin 显著抑制了 MCF-7 和 MDA-MB-231 细胞的增殖,以剂量依赖的方式.
奎尔丁治疗导致MCF-7细胞中BIRC5,CDK1和HSP90AA1的表达减少.
网络药理学分析预测了参与Hedyotis diffusa抗BRCA活性的关键目标和途径.

结论:

奎尔因其抗BRCA作用而被确定为Hedyotis diffusa的关键活性成分.
奎瑞会影响乳腺癌细胞中关键基因 (BIRC5,CDK1,HSP90AA1) 的表达.
这项研究提供了证据,支持Hedyotis diffusa在治疗BRCA的治疗潜力.

关键词:

黑底 (Hedyotis diffusa) 是一个扩散的植物.乳腺癌乳腺癌乳腺癌网络药理学网络药理学文素 (Quercetin) 是一种文素.

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