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限制饮食特征和大脑形态:一项基于儿科人口的研究
C P M Steegers1, M E J Deen1, P W Jansen1,2,3
1Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
The International journal of eating disorders
|April 26, 2025
概括
体重指数标准偏差得分 (BMI-SDS) 和节制饮食 (RE) 显示了儿童与大脑形态的性别特异关联. 与男孩相比,女孩在BMI-SDS,RE和大脑体积之间表现出更复杂的关系.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿科 儿科 儿科
背景情况:
- 神经性厌食症是一种限制性饮食障碍,与大脑结构的改变有关,主要是女性.
- 在一般儿科患者中,关于节制饮食 (RE),体重指数标准偏差得分 (BMI-SDS) 和大脑形态之间的关系的理解有限.
- 研究这些关联中的潜在性别差异对于理解典型的大脑发育至关重要.
研究的目的:
- 检查9岁儿童的BMI-SDS和大脑形态之间的关联.
- 为了研究节制饮食 (RE) 与大脑形态学之间的关系,考虑到性别差异.
- 确定BMI-SDS和RE是否与儿科队列中的灰质 (GM) 和白质 (WM) 量有关.
主要方法:
- 在以人口为基础的R世代研究中利用了2729名儿童 (9岁) 的数据.
- 用荷兰生长曲线调整性别和年龄的BMI-SDS计算.
- 使用荷兰饮食行为问卷评估RE,并通过结构磁共振成像和FreeSurfer分析大脑体积.
主要成果:
- 在女孩中,BMI-SDS与内和区域大脑总体积正相关,显示了与总灰质 (GM) 和白质 (WM) 的反转U形关联.
- 女孩的限制性饮食 (RE) 与内,WM和区域大脑体积 (经BMI-SDS校正) 呈现正线性关联,与杏仁体和胰岛体积呈反转U形关联.
- 男孩仅显示BMI-SDS和大脑体积之间的正线性关联,RE和大脑体积之间没有发现显著的关联.
结论:
- 在典型发育的儿童中,BMI和大脑体积之间的关联的大小和形状存在显著的性别差异.
- 限制饮食 (RE) 与女孩的特定大脑体积差异有关,但在男孩中并非如此.
- 建议进行纵向研究,以进一步阐明这些随时间推移的关联.
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